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TranscriptomicsIntrinsic age-dependent changes and cell-cell contacts regulate nephron progenitor lifespan
Purpose: To use single-cell RNA-Seq analysis of nephron progenitors in order to determine transcrptional differences as nephron progenitors age. Methods: Using a combination of FACS sorting and a Fluidigm Single-cell auto-prep system, we generated high-throughput RNA-SEQ data of nephron progenitors ...
ORGANISM(S): Mus musculus 
2015-12-23 | E-GEOD-66202 | biostudies-arrayexpress
TranscriptomicsNotch1 dose modulates endothelial gene expression
Purpose: To use RNA-Seq analysis of endothelial cell in various Notch1 alllels in order to determine transcrptional differencesas a consequence of Notch dose. Methods: Using a FACS sorting we generated high-throughput RNA-SEQ data of endothelials in various Notch1 alleles during development Results...
ORGANISM(S): Mus musculus 
2015-08-04 | E-GEOD-69276 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of epidermal gene expression from Presenilin (1&2)-null, RBPjk-null and wild-type litter mates
Analysis of differential gene expression in Psen-null and RBPjk-null epidermal keratinocytes. The hypothesis tested in the present study was that canonical Notch signals could be present at the beginning of epidermal stratification (E13.5) in the RBPj-null epidermis. If an early signal was preserved...
ORGANISM(S): Mus musculus 
2016-02-29 | E-GEOD-77813 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of total skin gene expression from presenilin (1&2)-null (PSmut), RBPjk-null (RBPjmut), Presenilin (1&2)-RBPjk-null (PSRmut) and wild-type (WT) littermates
Analysis of differential gene expression of total skin from different Notch signaling pathway mutants (specifically PSmut, RBPjmut, and PSRmut). Preselin1&2 are the core components of g-secretase enzyme which essential for the Notch receptor activation. RBPjk is the DNA-binding partner of the Notch ...
ORGANISM(S): Mus musculus 
2016-02-29 | E-GEOD-77887 | biostudies-arrayexpress
TranscriptomicsQuantitative Analysis of Notch mutant (Notch1&2-null, Psen1&2-null, RBPjk-null) and wild-type hair follicle transcriptomes by NGS
The goals of this study is to test whether NICD presence protects the RBPjk-null Hair Follicles by altering gene expression via association with other DNA binding proteins at P3, just before the conversion to TSLP-producing keratin cysts. Methods: Skin samples were embedded in OCT. Sectioned at 20μ...
ORGANISM(S): Mus musculus 
2016-02-29 | E-GEOD-77997 | biostudies-arrayexpress
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