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TranscriptomicsTranscription profiling of human cell lines reveals Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation
Neuroblastomas are tumors of the developing peripheral sympathetic nervous system, which originates from the neural crest. Twenty percent of neuroblastomas show amplification of the MYCN oncogene, which correlates with poor prognosis. The MYCN transcription factor can activate and repress gene expre...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8066 | biostudies-arrayexpress
TranscriptomicsYG001: A Usp7-Tip60 pathway regulates early adipogenesis
USP7, a dominant DUB activity in 3T3-L1 adipocytes and in mouse adipose tissue, increases Tip60 protein levels, and deubiquitinates Tip60 both in intact cells and in vitro. Treatment with a pan deubiquitinase (DUB) inhibitor, or knockdown of USP7, decreases adipogenesis. Transcriptome analysis revea...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-28587 | biostudies-arrayexpress
TranscriptomicsCD1d-restricted NKT cell function prevents insulin resistance in lean mice, and is regulated by adipocytes and is regulated by adipocytes
Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased i...
ORGANISM(S): Mus musculus 
2012-08-06 | E-GEOD-39534 | biostudies-arrayexpress
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