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TranscriptomicsGlioma stem cell treatment with MELK-signaling inhibitors
Glioblastoma multiforme (GBM) is a highly lethal brain tumor. Due to resistance to current therapies, patient prognosis remains poor and development of novel and effective GBM therapy is crucial. Glioma stem cells (GSCs) have gained attention as therapeutic target in GBM due to their relative resist...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-50227 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain tumor cells to assess endogenous mRNA fluctuations detects a microRNA signal in an in vivo expression set of mRNAs.
Background: microRNAs (miRNAs) are approximately 21 nucleotide non-coding transcripts capable of regulating gene expression. The most widely studied mechanism of regulation involves binding of the miRNA to a target mRNA, usually in its 3’ untranslated region (UTR). As a result, translation of t...
ORGANISM(S): Homo sapiens 
2009-04-25 | E-GEOD-8692 | biostudies-arrayexpress
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