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TranscriptomicsHuman Organotypic Smoke Street
The aim of this study was to develop human bronchial and nasal epithelium culture models that are relevant to investigate the impact of cigarette smoke (CS) observed in vivo in respiratory tract tissues in contact with inhaled CS. We used two organotypic cultures generated from primary cells derive...
ORGANISM(S): Homo sapiens 
2013-12-11 | E-MTAB-1721 | biostudies-arrayexpress
TranscriptomicsCigarette smoke exposure of human organotypic cultures of buccal and gingival mucosa
Oral mucosa of smokers is subject to cigarette smoke (CS)-related cytological, genomic, and transcriptional changes that could potentially lead to the development of mouth diseases. In order to further characterize CS effects, we took advantage of two human organotypic in vitro models of the buccal ...
ORGANISM(S): Homo sapiens 
2014-08-30 | E-MTAB-2251 | biostudies-arrayexpress
TranscriptomicsThe Response of Human Respiratory Organotypic Cultures to Repeated Cigarette Smoke Exposure
Exposure to cigarette smoke (CS) is etiologically linked to the development of fatal respiratory diseases, and there is a need to understand the mechanisms whereby CS causes damage. While animal models have provided valuable insights into smoking-related respiratory tract damage, modern toxicity tes...
ORGANISM(S): Homo sapiens 
2014-09-30 | E-MTAB-2250 | biostudies-arrayexpress
TranscriptomicsSystems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures (miRNA dataset).
Cigarette smoke (CS) has been reported to increase predisposition to oral cancer and is also recognized as a risk factor for many conditions including periodontal diseases, gingivitis, and other benign mucosal disorders. Smoking cessation remains the most effective approach for minimizing the risk o...
ORGANISM(S): Homo sapiens 
2018-03-01 | E-MTAB-6545 | biostudies-arrayexpress
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