Sort   by:  
 Page size 
TranscriptomicsSOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B cell development
Here we use a microarray approach to define at the molecular level the consequences of SOX7-mediated effect on B lymphopoiesis and progenitor proliferation. Transcriptome profiling analysis was performed on two subpopulations expressing low and high level of SOX7::GFP. Bone marrow cells extracted fr...
ORGANISM(S): Mus musculus 
2016-08-09 | E-GEOD-65552 | biostudies-arrayexpress
TranscriptomicsRUNX1B expression distinguishes megakaryocytic and erythroid lineage fate in adult hematopoiesis
The Core Binding Factor (CBF) protein RUNX1 is a master regulator of definitive hematopoiesis, crucial for hematopoietic stem cell (HSC) emergence during ontogeny, which also plays vital roles in adult mice, in regulating the correct specification of numerous blood lineages. Akin to the other mamma...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-68958 | biostudies-arrayexpress
TranscriptomicsRNA-seq experiment comparing the transcriptomes of mESC derived primary endothelial cells expressing different levels of TAZ-CAMTA1
TAZ-CAMTA1 (TC) is one of two fusion proteins known to define Epithelioid Hemangioendothelioma (EHE), a rare vascular sarcoma. It is thought that TC expression represents the initiating event in EHE development. We have developed a model for studying EHE through the differentiation of mESCs into pri...
ORGANISM(S): Mus musculus 
2025-08-08 | E-MTAB-11882 | biostudies-arrayexpress
GenomicsRUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence (DamID-seq)
During ontogeny the transcription factor RUNX1 governs the emergence of definitive hematopoietic cells from specialized endothelial cells, called hemogenic endothelium (HE). The ultimate consequence of this endothelial-to-hematopoietic transition is the concomitant activation of the hematopoietic pr...
ORGANISM(S): Mus musculus 
2014-08-05 | E-GEOD-55308 | biostudies-arrayexpress
TranscriptomicsRUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence (RNA-seq)
During ontogeny the transcription factor RUNX1 governs the emergence of definitive hematopoietic cells from specialized endothelial cells, called hemogenic endothelium (HE). The ultimate consequence of this endothelial-to-hematopoietic transition is the concomitant activation of the hematopoietic pr...
ORGANISM(S): Mus musculus 
2014-08-05 | E-GEOD-55310 | biostudies-arrayexpress
GenomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-40235 | biostudies-arrayexpress
TranscriptomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2013-02-11 | E-GEOD-39662 | biostudies-arrayexpress
TranscriptomicsDecoding the Transcriptional Program for Blood Development from Single Cell Gene Expression Measurements
Blood and cardiovascular development represent paradigms of embryonic organ formation, with increasingly specialised cells generated from early mesoderm. Here, we map the progression of mesoderm towards blood by single cell expression analysis of 3,934 cells, aiming to capture an entire embryo equiv...
ORGANISM(S): Mus musculus 
2015-02-09 | E-GEOD-61470 | biostudies-arrayexpress
Sort   by:  
 Page size