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ProteomicsKetone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding
Time-restricted feeding (TRF) has gained attention as a dietary regimen that promotes metabolic health. This study sought to determine if ketone flux in skeletal and cardiac muscles plays an essential role in conferring the health benefits of an intermittent TRF (iTRF) schedule. Notably, we found th...
ORGANISM(S): Mus Musculus (mouse) 
2024-02-09 | PXD047114 | JPOST Repository
ProteomicsDisruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis and lean mass
STIM1 is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in store operated Ca2+ entry (SOCE), an ancient and ubiquitous signaling pathway. Whereas STIM1 is indispensable during development, its biological and metabolic functions in mature muscle ...
ORGANISM(S): Mus Musculus (mouse) 
2021-12-30 | PXD030674 | JPOST Repository
ProteomicsPyruvate-supported flux through medium chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles
Even-chain acylcarnitine (AC) metabolites, most of which are generated as byproducts of incomplete fatty acid oxidation (FAO), are viewed as biomarkers of mitochondrial lipid stress attributable to one or more metabolic bottlenecks in the beta-oxidation pathway. The origins and functional implicatio...
ORGANISM(S): Mus Musculus (mouse) 
2023-04-14 | PXD040326 | JPOST Repository
ProteomicsMetformin Impairs Intestinal Fructose Metabolism
Objective: To investigate the effects of metformin on intestinal carbohydrate metabolism in vivo. Method: Male mice preconditioned with a high-fat, high-sucrose diet were treated orally with metformin or a control solution for two weeks. Fructose metabolism, glucose production from fructose, and p...
ORGANISM(S): Mus Musculus (mouse) 
2024-04-27 | PXD041833 | JPOST Repository
ProteomicsComprehensive respiratory phenomics across multiple models of mitochondrial protein hyperacylation reveals a paradoxically marginal impact on bioenergetics
Acyl CoA metabolites derived from catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translation modifications (PTMs). Mass spectrometry-based detection of thousands of acyl-PTMs scattered throughout the proteome has established...
ORGANISM(S): Mus Musculus (mouse) 
2019-02-07 | PXD011375 | JPOST Repository
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