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Poly (ADP-ribose) polymerase inhibitors (PARPi) induce cytotoxicity in homologous recombination repair (HRR)-deficient cancers by causing PARP1 to become trapped on chromatin, resulting in irreparable replication-associated DNA damage. Cancer cells commonly develop resistance to PARPi, with a recent...
ORGANISM(S): Homo sapiens (Human) 
2026-04-15 | PXD071389 | Pride
Synthetic lethal CRISPR screen in MCF10A FBXW7 isogenic models
ORGANISM(S): Homo sapiens 
CRISPR screen data
ORGANISM(S): Homo sapiens 
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