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TranscriptomicsEnhancer Transcripts Mark Active Estrogen Receptor Binding Sites using GRO-seq
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ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-43836 | biostudies-arrayexpress
TranscriptomicsEnhancer Transcripts Mark Active Estrogen Receptor Binding Sites
In this study, we used Global Run-On sequencing (GRO-seq), a method that assays the genome-wide location and orientation of all active RNA polymerases. We generated a global profile of active transcription at ERM-NM-1 binding sites in MCF-7 human breast cancer cells in response to short time course ...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-43835 | biostudies-arrayexpress
TranscriptomicsERalpha ChIP-chip from HeLA-ER cells treated with E2
We are studying the mechanisms by which the estrogen receptor, ERalpha, is recruited to and regulates genes with a non-direct DNA binding. We performed ChIP-chip for ERalpha in E2 treated HeLa-ER cells, and looked at 19000 RefSeq genes to determine binding patterns of the receptor at promoters. Th...
ORGANISM(S): Homo sapiens 
2011-02-22 | E-GEOD-22099 | biostudies-arrayexpress
TranscriptomicsIdentification and functional characterization of long noncoding RNAs in breast cancer
In this study, we have integrated RNA-seq data from subcellular fractionated RNA (i.e., cytoplasm, nucleoplasm, and chromatin-associated) with GRO-seq data using a novel bioinformatics pipeline. This has yielded a comprehensive catalog of polyadenylated lncRNAs in MCF-7 cells, about half of which ha...
ORGANISM(S): Homo sapiens 
2015-07-30 | E-GEOD-63189 | biostudies-arrayexpress
TranscriptomicsPELP1 ChIP-chip from MCF-7 cells
Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a transcriptional coactivator that has previously been shown to collaborate with nuclear receptors. Evidence from other groups suggest that PELP1 may stimulate transcription by displacing the linker histone H1 and/or by recruiting the l...
ORGANISM(S): Homo sapiens 
2014-04-24 | E-GEOD-22254 | biostudies-arrayexpress
TranscriptomicsGlobal Analysis of the Immediate Transcriptional Effects of Estrogen Signaling Reveals a Rapid, Extensive, and Transient Response
We report the immediate effects of estrogen signaling on the transcriptome of breast cancer cells using Global Run-On and sequencing (GRO-seq). We found that estrogen signaling directly regulates a strikingly large fraction of the transcriptome in a rapid, robust, and unexpectedly transient manner. ...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-27463 | biostudies-arrayexpress
TranscriptomicsSignaling Pathways Deferentially Affect RNA Polymerase II Initiation, Pausing, and Elongation in Human Cells: TNF-alpha dependent signaling in AC16 cells
We used Global Run-on and Sequencing (GRO-seq) to measure the rate of transcription elongation by RNA polymerase II (Pol II) following gene activation. We observed that Pol II elongation rates can vary as much as 4-fold at different genomic loci and in response to two distinct cellular signaling pa...
ORGANISM(S): Homo sapiens 
2013-04-10 | E-GEOD-41323 | biostudies-arrayexpress
TranscriptomicsSignaling Pathways Deferentially Affect RNA Polymerase II Initiation, Pausing, and Elongation in Human Cells: Estrogen dependent signaling in MCF-7 cells
We used Global Run-on and Sequencing (GRO-seq) to measure the rate of transcription elongation by RNA polymerase II (Pol II) following gene activation. We observed that Pol II elongation rates can vary as much as 4-fold at different genomic loci and in response to two distinct cellular signaling pa...
ORGANISM(S): Homo sapiens 
2013-04-10 | E-GEOD-41324 | biostudies-arrayexpress
UnknownTime-resolved diffraction of shock-released SiO2 and diaplectic glass formation.
Not available
S-EPMC5684137 | biostudies-literature
UnknownUltrafast visualization of crystallization and grain growth in shock-compressed SiO2.
Not available
S-EPMC4569796 | biostudies-literature
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