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ProteomicsAnalysis of the cellular effect of 1α,25-dihydroxyvitamin D3 on lung NCI-H441 cells
Low serum levels or deficiency of 1α,25-dihydroxyvitamin D3 (VD3) are associated with a higher mortality in trauma patients with sepsis or acute respiratory distress syndrome, although the molecular mechanisms behind this observation are not yet understood. VD3 is known to stimulate lung maturity, a...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040622 | Pride
Vitamin d3 Nci-h441 cells Alveolar-capillary barrier Lung Isobaric labelling Biomarker 
TranscriptomicsDeletion of DMD exon 52 in the pig results in fulminant muscular dystrophy
Duchenne muscular dystrophy (DMD) is caused by mutations in the X-linked dystrophin (DMD) gene. The absence of dystrophin protein leads to progressive muscle weakness and wasting, disability and death. To establish a tailored large animal model of DMD, we deleted DMD exon 52 in male pig cells by gen...
ORGANISM(S): Sus scrofa 
2013-08-06 | E-GEOD-44096 | biostudies-arrayexpress
TranscriptomicsImmunosuppressive capabilities of mesenchymal stromal cells are maintained under hypoxic growth conditions and after gamma irradiation
To investigate factors that might influence the T-cell suppressive capabilities of mesenchymal stroma cells, T-cell suppressive and non-suppressive mesenchymal stroma cells were compared. Immunosuppressive capabilities of MSCs was determined via T-cell proliferation assay.
ORGANISM(S): Homo sapiens 
2015-01-20 | E-MTAB-2396 | biostudies-arrayexpress
TranscriptomicsLetrozole (Femara) early and late responses to treatment
In the present investigation, we have exploited the opportunity provided by neoadjuvant treatment of a group of postmenopausal women with large operable or locally advanced breast cancer (in which therapy is given with the primary tumour remaining within the breast) to take sequential biopsies of th...
ORGANISM(S): Homo sapiens 
2010-07-28 | E-GEOD-20181 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human sequential breast cancer biopsies during letrozole treatment
In the present investigation, we have exploited the opportunity provided by neoadjuvant treatment of a group of postmenopausal women with large operable or locally advanced breast cancer (in which therapy is given with the primary tumour remaining within the breast) to take sequential biopsies of th...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5462 | biostudies-arrayexpress
TranscriptomicsOncogenic RAS primes primary acute myeloid leukemia blasts for differentiation
RAS mutations are frequently found among AML patients, generating a constitutively active signaling protein changing cellular proliferation, differentiation and apoptosis. We previously showed that treatment of AML patients with high-dose cytarabine (HDAC) is preferentially beneficial for those with...
2015-11-20 | E-MTAB-2090 | biostudies-arrayexpress
TranscriptomicsUpregulation of immunoproteasome subunits in myositis indicates active inflammation with involvement of antigen presenting cells, CD8 T-cells and IFNM-NM-3
Objective: In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and upregulation of MHC-I expression implies increased antigen presentation and involvement of the proteasome system. To decipher the role of immunoproteasomes in myositis, we investigated individual cell...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-58173 | biostudies-arrayexpress
UnknownDo Surgeons Treat Their Patients Like They Would Treat Themselves?
Not available
S-EPMC4586191 | biostudies-literature
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