Sort   by:  
 Page size 
TranscriptomicsChIP-chip from DmD8 cells with Twist antibodies after 30 minutes Notch activation
The transcription factor Twist is a critical cooperating factor that confers transcriptional specificity to the Notch pathway in muscle progenitor cells (DmD8) ChIP analysis of Twi show that Twist binding is significantly enriched in Notch responsive region in DmD8 cells 3 replicates of Twist ChIP a...
ORGANISM(S): Drosophila melanogaster 
2010-07-27 | E-GEOD-22650 | biostudies-arrayexpress
TranscriptomicsChIP-chip from Kc cells with Su(H) antibodies after 30 minutes Notch activation
During hematopoiesis, Notch regulates both the emergence of stem and progenitor cells and the subsequent cell fate choices and differentiation. To investigate how Notch drives cells to differentiate we have used a genome-wide approach to identify direct Notch targets in Drosophila Kc cells. These da...
ORGANISM(S): Drosophila melanogaster 
2013-03-08 | E-GEOD-43132 | biostudies-arrayexpress
TranscriptomicsNotch targets in KC Drosophila cells
To identify genes upregulated in response to Notch signalling in KC cells. Keywords: Expression analysis at a single timepoint (30' after Notch activation) KC cells were obtained from Dr Martin Zeidler. Control versus Notch activated KC cells: mRNA was extracted from KC cells incubated in the absenc...
ORGANISM(S): Drosophila melanogaster 
2010-06-23 | E-GEOD-9965 | biostudies-arrayexpress
TranscriptomicsGene expression changes in Nicd induced wing disc hyperplasia
The outcome of Notch proliferation on proliferation depends on the context. In Drosophila wing imaginal discs Notch activation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand te underlying mechanisms we have used genomic strategies to identify the Notch...
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-41428 | biostudies-arrayexpress
TranscriptomicsNotch-regulated genes in wing disc hyperplasia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-41429 | biostudies-arrayexpress
TranscriptomicsTranscriptional dynamics elicited by a short pulse of Notch activation.
Cellular responses to signalling pathways are often highly dynamic, however most analyses of developmental signalling pathways focus on a single endpoint. Here we have analyzed the temporal changes in transcription following a short Notch activation treatment and have related these to the recruitmen...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-35557 | biostudies-arrayexpress
TranscriptomicsSu(H) bound regions in Nicd induced wing-disc hyperplasia
The outcome of Notch activation on proliferation depends on cellular context. In Drosophila wing discs Notch activation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms we have used genomic strategies to identify the Notch-Su(H)...
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-41426 | biostudies-arrayexpress
TranscriptomicsGene expression changes in Su(H) induced wing disc hyperplasia
The outcome of Notch activation of proliferation depends on cellular context. In Drosophila wing discs Notch pathway overactivation results in hyperplasia. To understand the mechanisms we have used genomic strategies to indetify the Notch-S(H) target genes directly regulated in wing disc hyperplasia...
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-41427 | biostudies-arrayexpress
TranscriptomicsSu(H) bound regions in Su(H) induced wing-disc hyperplasia
The outcome of Notch activation on proliferation depends on cellular context. In Drosophila wing discs Notch activation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms we have used genomic strategies to identify the Notch-Su(H)...
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-41425 | biostudies-arrayexpress
TranscriptomicsChIP-chip time-course from DmD8 cells with Su(H) antibody after 0, 10, 20, 30 40, 60 and 100 minutes Notch activation
Cellular responses to signalling pathways are often highly dynamic, however most analyses of developmental signalling pathways focus on a single endpoint. We have analyzed the temporal changes in transcription following a short Notch activation treatment and related these to the recruitment of the N...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-35719 | biostudies-arrayexpress
Sort   by:  
 Page size