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TranscriptomicsStable inhibitory activity of regulatory T cells requires the transcription factor Helios
The maintenance of immune homeostasis requires regulatory T cells (Tregs). Given their intrinsic self-reactivity, Tregs must stably maintain a suppressive phenotype to avoid autoimmunity. We report that impaired expression of the transcription factor (TF) Helios by FoxP3+ CD4 and Qa-1-restricted CD8...
ORGANISM(S): Mus musculus 
2015-09-15 | E-GEOD-73015 | biostudies-arrayexpress
GenomicsCell‐intrinsic functions of Bhlhe40 in activated B cells and TFH cells restrain the GC reaction and prevent lymphomagenesis
Cell‐intrinsic functions of Bhlhe40 in activated B cells and TFH cells restrain the GC reaction and prevent lymphomagenesis
PRJNA773937 | ENA
Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
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