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TranscriptomicsExpression profiling of B.subtils SMY wild-type vs. (p)ppGpp0 cells upon amino acid starvation.
Cells constantly adjust their metabolism in response to environmental conditions, yet major mechanisms underlying survival remain poorly understood. We discover a post-transcriptional mechanism that integrates starvation response with GTP homeostasis to allow survival, enacted by the nucleotide (p)p...
ORGANISM(S): Bacillus subtilis 
2012-11-01 | E-GEOD-39758 | biostudies-arrayexpress
TranscriptomicsExpression profiling of B.subtils SMY wild-type, (p)ppGpp0, M-NM-^TcodY (p)ppGpp0 and guaB- (p)ppGpp0 cells upon amino acid starvation (RHX) or guanosine (Guo) treatment.
The nucleotide (p)ppGpp is crucial for viability during amino acid limitation in bacteria, yet how it accomplishes this remains unknown. We found that the absence of (p)ppGpp in Bacillus subtilis cells leads to multiple amino acid auxotrophy, and that (p)ppGpp allows for prototrophy by reducing GTP ...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2013-11-01 | E-GEOD-41501 | biostudies-arrayexpress
TranscriptomicsExpression profiling of B.subtils ftsZ depletion cells with ftsZ induced or uninduced for 1 or 2hrs.
The past twenty years have seen tremendous advances in our understanding of the mechanisms underlying bacterial cytokinesis, particularly the composition of the division machinery and the factors controlling its assembly. At the same time, however, we understand very little about the relationship be...
ORGANISM(S): Bacillus subtilis 
2015-01-01 | E-GEOD-56753 | biostudies-arrayexpress
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