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ProteomicsNitration of Tyrosines In Complement Factor H Domains Alters Its Immunological Activity and Mediates A Pathogenic Role In Age Related Macular Degeneration
Nitrosative stress has been implicated in the pathogenesis of age related macular degeneration (AMD). Tyrosine nitration is a unique type of post translational modification that occurs in the setting of inflammation and nitrosative stress. To date, the significance and functional implications of tyr...
ORGANISM(S): Homo sapiens (Human) 
2017-08-29 | PXD005613 | Pride
Complement factor h Nitrotyrosine Cfh Macular degeneration 
ProteomicsThioredoxin reduces complement factor H and alters its complement regulatory function
Complement factor H (CFH) is an enzyme responsible for inactivating components of the complement cascade, thus limiting the downstream effector mechanisms which would otherwise occur were the process to continue unregulated. In view of the close structural and functional homology between β2GPI and C...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD009558 | Pride
Complement factor h Thioredoxin Disulfide bonds 
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