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TranscriptomicsCell of origin in AML: Susceptibility to MN1-induced transformation is regulated by the MEIS1/abdB-like HOX protein complex
The molecular mechanism defining susceptibility of normal cells to oncogenic transformation may be a valuable therapeutic target. We characterized the cell of origin and its critical pathways in MN1 leukemias. Common myeloid (CMP), but not granulocyte-macrophage progenitors (CMP) could be transforme...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-22923 | biostudies-arrayexpress
TranscriptomicsHOXA9 is required for survival in human MLL rearranged acute leukemias
Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biological characteristics and often have an unfavorable prognosis. Gene expression analyses demonstrate a distinct profile for MLL-rearranged leukemias with consistent high-level expression of select...
ORGANISM(S): Homo sapiens 
2009-01-01 | GSE13714 | GEO
TranscriptomicsActivation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells
Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells is an important component of AML development We generated either MLL-AF9 mediated murine leukemias that originate from committed progenitor (GMP) cells or Hoxa9/Meis1a mediated murine leukemias that or...
ORGANISM(S): Mus musculus 
2010-03-23 | E-GEOD-20377 | biostudies-arrayexpress
TranscriptomicsshRNA profiling of human MLL cells reveals HOXA9 is required for survival in human MLL rearranged acute leukemias
Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biological characteristics and often have an unfavorable prognosis. Gene expression analyses demonstrate a distinct profile for MLL-rearranged leukemias with consistent high-level expression of select...
ORGANISM(S): Homo sapiens 
2009-01-26 | E-GEOD-13714 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse isolated granulocyte macrophage progenitors were incubated with a retrovirus that expressed either GFP or MLL-AF9 and GFP
Leukemias and other cancers possess a rare population of cells capable of self-renewal, and eradication of these cancer stem cells is likely necessary for long-term cancer-free survival. Given that both normal and cancer stem cells are capable of self-renewal the extent to which cancer stem cells re...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4416 | biostudies-arrayexpress
UnknownA UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription.
Not available
S-EPMC5574165 | biostudies-literature
UnknownPhotodriven Charge Accumulation and Carrier Dynamics in a Water-Soluble Carbon Nitride Photocatalyst.
Not available
S-EPMC8048561 | biostudies-literature
GenomicsEpigenetic profiling of hematopoietic stem cells and leukemia stem cells
The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations that involve the Mixed Lineage Leukemia (MLL) gene. We identified the MLL-fusion targets in a murine MLL-AF9 leukemia model, and conducted epigenetic profiling for H3K7...
ORGANISM(S): Mus musculus 
2011-09-13 | E-GEOD-29130 | biostudies-arrayexpress
UnknownKRas(G12D)-evoked leukemogenesis does not require β-catenin.
Not available
S-EPMC4367949 | biostudies-literature
UnknownASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.
Not available
S-EPMC5454368 | biostudies-literature
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