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TranscriptomicsNKT-10 cells represent a novel invariant NKT cell subset with regulatory characteristics
We compared splenic Va14i NKT cells from C57BL/6 control mice and from mice injected 4 weeks earlier intravenously with 4ug/mouse of the iNKT cell antigen alpha-galactosylceramide (aGalCer). These mice were either left unstimulated or were stimulated with 1ug/mouse aGalCer i.v.. All mice were female...
ORGANISM(S): Mus musculus 
2014-07-25 | E-GEOD-47959 | biostudies-arrayexpress
TranscriptomicsEffect of Th-POK deficiency on global gene expression in liver Va14i NKT cells
We sought to identify genes regulated by the transcription factor Th-POK (Zbtb7b) in liver Va14i NKT cells, by RNA microarray analysis of global gene expression in Va14i NKT cells from mice homozygous for the Th-POK-inactivating hd point mutation as compared with the same cell population isolated fr...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-34179 | biostudies-arrayexpress
TranscriptomicsIL-10 from intestinal macrophages prevents excessive innate immune responses to bacteria by limiting IL-23 synthesis
Innate immune responses must be regulated in the intestine to prevent excessive inflammation. Here, using gene reporter mice, we show that a subset of mouse colonic macrophages constitutively produced the anti-inflammatory cytokine IL-10. In mice infected with Citrobacter rodentium, which is consid...
ORGANISM(S): Mus musculus 
2015-05-12 | E-GEOD-58677 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine intraepithelial lymphocytes (IEL) vs. TCR ab+ CD8b+ and TCR gd+ cells
Mouse small intestine intraepithelial lymphocytes (IEL) that express a ab TCR and CD8aa homodimers are an enigmatic T cell subset, as their specificity and in vivo function remain to be defined. To gain insight into the nature of these cells, we performed global gene expression profiling using micr...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5355 | biostudies-arrayexpress
TranscriptomicsS mansoni infection B cell comparison
The helminth Schistosoma Mansoni is known to generate a regulatory B cell population that can suppress in multiple murine experimental models. Microarray comparison allows for a greater understanding as to how these cells are generated and their implications in immune regulation.
ORGANISM(S): Mus musculus 
2014-03-28 | E-MTAB-2100 | biostudies-arrayexpress
UnknownGenome-wide association study of kidney function decline in individuals of European descent.
Not available
S-EPMC4425568 | biostudies-literature
GenomicImpact of Genetic Polymorphisms on Human Immune Cell Gene Expression

While many genetic variants have been associated with risk for human diseases, how these variants affect gene expression in various cell types remains largely unknown. To address this gap, the DICE (Database of Immune Cell Expression, Expression quantitative trait loci (eQTLs) and Epigenomics) pr...

phs001703 | dbGaP
UnknownNew loci associated with kidney function and chronic kidney disease.
Not available
S-EPMC2997674 | biostudies-literature
UnknownGenetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium.
Not available
S-EPMC3596171 | biostudies-literature
UnknownIntegration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.
Not available
S-EPMC3607468 | biostudies-literature
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