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MetabolomicsUntargeted metabolomics as a hypothesis-generation tool in plant protection product discovery: Highlighting the potential of trehalose and glycerol metabolism of fungal conidiospores as novel targets

INTRODUCTION: The production of high quality and safe food represents a main priority for the agri-food sector in the effort to sustain the exponentially growing human population. Nonetheless, there are major challenges that require the discovery of new, alternative, and improved...

2020-09-08 | MTBLS1565 | MetaboLights
TranscriptomicsSperm but not oocyte DNA methylome is inherited by zebrafish early embyros
5-methylcytosine is a major epigenetic modification sometimes called "the fifth nucleotide". However, our knowledge of how offspring inherit the DNA methylome from parents is limited. We generated nine single-base resolution DNA methylomes including zebrafish gametes and early embryos. The...
ORGANISM(S): Danio rerio 
2013-05-20 | E-GEOD-44075 | biostudies-arrayexpress
MetabolomicsSerine Metabolism Tunes Immune Responses To Promote Oreochromis niloticus Survival upon Edwardsiella tarda Infection
Overactive immune response is a critical factor triggering host death upon bacterial infection. However, the mechanism behind the regulation of excessive immune responses is still largely unknown, and the corresponding control and preventive measures are also to be explored. In this study, we find t...
2021-08-18 | MTBLS2974 | MetaboLights
UnknownGenome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve.
Not available
S-EPMC3413122 | biostudies-literature
MetabolomicsMetabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs)
Fibroblasts can be directly reprogrammed to induced renal tubular epithelial cells (iRECs) using four transcription factors. These engineered cells may be used for disease modeling, cell replacement therapy or drug and toxicity testing. Direct reprogramming induces drastic changes in the transcripti...
2021-08-20 | MTBLS608 | MetaboLights
GenomicsGenome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve
We provide ChIP-Seq analysis of Egr2 and Sox10 transcription factor binding in Schwann cells of rat peripheral nerve ChIP-Seq analysis of Egr2 and Sox10 binding in P15 rat sciatic nerve. Wiggle files of negative log of posterior probability determined by Mosaics.
ORGANISM(S): Rattus norvegicus 
2012-04-01 | E-GEOD-35132 | biostudies-arrayexpress
UnknownGenome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.
Not available
S-EPMC6066359 | biostudies-literature
TranscriptomicsChromatin immunoprecipitation to identify binding sites for Gata4, Mef2a, Nkx2.5, Srf, p300, Pol_II, H3ac, H3K4me1 in mouse cardiomyocyte cell line, HL1
The aim of the experiment was to identify genome wide binding sites for Gata4, Mef2a, Nkx2.5, Srf, p300, Pol_II, H3ac, H3K4me1 by using Chromatin Immunoprecipitation followed by microarray analysis (ChIP-chip) in HL1 cells.
ORGANISM(S): Mus musculus 
2011-01-05 | E-TABM-378 | biostudies-arrayexpress
UnknownSmall Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression.
Not available
S-EPMC4486263 | biostudies-literature
GenomicsIdentification of transcription factor Srf binding sites and histone 3 actetylated regions in mouse cardiomyocytes
We investigated the cardiac transcription network driven by the DNA-binding key factor Srf in combination with epigenetic marks of histone 3 acetylation (H3ac). Srf has been shown to play a key role in cardiac cell growth and muscle gene regulation. However, we still have limited understanding of th...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-19065 | biostudies-arrayexpress
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