Sort   by:  
 Page size 
ProteomicsK27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
Conjugation of ubiquitin (Ub) to numerous substrate proteins regulates virtually all cellular processes. Eight distinct ubiquitin polymer linkages specifying different functional outcomes are generated in cells. However, the roles of some atypical poly-ubiquitin topologies, in particular linkages vi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD023579 | Pride
Ubiquitin Proteomics K27 
ProteomicsEfficient checkpoint signaling depends on the integrated activities of Bub1 and the RZZ complex
Kinetochore localized Mad1 is essential for generating a “wait anaphase” signal during mitosis hereby ensuring accurate chromosome segregation. Inconsistent models for the function and quantitative contribution of the two mammalian Mad1 kinetochore receptors: Bub1 and the Rod-Zwilch-ZW10 (RZZ) compl...
ORGANISM(S): Homo sapiens (Human) 
2019-02-19 | PXD012235 | Pride
Mitosis proteomics bub1 
TranscriptomicsGenomeâ??wide transcriptional profiling with spatial resolution identifies Bone Morphogenetic Protein signaling as essential regulator of zebrafish cardiomyocyte regeneration.
In contrast to mammals, zebrafish regenerate heart injuries via proliferation of cardiomyocytes located at the wound border. Here, we show that tomo-seq can be used to identify whole-genome transcriptional profiles of the injury zone, the border zone and the healthy myocardium. Interestingly, the bo...
ORGANISM(S): Danio rerio 
2016-01-11 | E-GEOD-74652 | biostudies-arrayexpress
UnknownK27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
Not available
S-SCDT-10_15252-EMBJ_2021110145 | biostudies-other
ProteomicsLarge scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 disease specific mechanisms and vulnerabilities.
Coronaviruses constitute a constant threat as documented by the recent emergence of SARS-CoV-2 that has caused more than 2,5 million deaths worldwide. Despite this our understanding of coronaviruses and how they interact with their host is very limited. Here we describe a novel phage display library...
ORGANISM(S): Homo sapiens (Human) 
2021-10-29 | PXD025410 | Pride
Sars-cov2 Protein interaction Proteomics 
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
BAT transcriptome from control and brown adipocyte-specific Rev-erbα/β double knockout mice housed at thermoneutrality or cold-challenged for 6 hours. Brown adipose tissue (BAT) samples were collected from control and brown adipocyte-specific Rev-erbα/β double knockout mice (Ucp1-Cre; Nr1d1/2 fl/fl)...
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17580 | biostudies-arrayexpress
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
Transcriptome from immortalized murine brown adipocytes BMC. Cells were transfected with siRNA construct #1 or construct #2 (pool) or non-targeting control on day 3 of differentiation and harvested on day 7 of differentiation.
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17577 | biostudies-arrayexpress
Sort   by:  
 Page size