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TranscriptomicsSIRT1 but not its increased expression is essential for lifespan extension in caloric restricted mice.
The SIRT1 deacetylase is one of the best-studied potential mediators of some of the anti-aging effects of calorie restriction (CR); but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespa...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-46895 | biostudies-arrayexpress
TranscriptomicsComparison of the long-term effects of calorie restriction without malnutrition on global gene expression profiles of rat and human skeletal muscle [Rat]
With the population of older and overweight individuals on the rise in the Western world, there is an ever greater need to slow the aging processes and reduce the burden of age-associated chronic disease that would significantly improve the quality of human life and reduce economic costs. Caloric re...
ORGANISM(S): Rattus norvegicus 
2013-08-01 | E-GEOD-38062 | biostudies-arrayexpress
TranscriptomicsComparison of the long-term effects of calorie restriction without malnutrition on global gene expression profiles of rat and human skeletal muscle [Human]
With the population of older and overweight individuals on the rise in the Western world, there is an ever greater need to slow the aging processes and reduce the burden of age-associated chronic disease that would significantly improve the quality of human life and reduce economic costs. Caloric re...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-38012 | biostudies-arrayexpress
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