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ProteomicsTIPRL1 and its ATM-dependent phosphorylation modulate the DNA Damage Response to promote radiotherapy resistance in head and neck cancer
TIPRL1 (target of rapamycin signaling pathway regulator-like 1) is a known interactor and inhibitor of protein phosphatases PP2A, PP4 and PP6 – all pleiotropic modulators of the DNA Damage Response (DDR). Here, we describe a new role for TIPRL1 in the radiotherapy (RT) response of Head and Neck Squa...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD044931 | Pride
Ataxia telangiectasia mutated (atm) kinase/ dna damage response (ddr)/ head and neck squamous cell carcinoma (hnscc)/ radioresistance/ target of rapamycin signaling pathway regulator-like 1 (tiprl1) 
TranscriptomicsFriedreichâ??s Ataxia Induced Pluripotent Stem Cells Recapitulate GAAâ?¢TTC Triplet-Repeat Instability
The inherited neurodegenerative disease Friedreichâ??s ataxia (FRDA) is caused by hyperexpansion of GAAâ?¢TTC trinucleotide repeats within the first intron of the FXN gene, encoding the mitochondrial protein frataxin. Long GAAâ?¢TTC repeats causes heterochromatin-mediated silencing and loss of frata...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-22651 | biostudies-arrayexpress
UnknownAnalysis of DNA double-strand break response and chromatin structure in mitosis using laser microirradiation.
Not available
S-EPMC3001094 | biostudies-literature
UnknownDiscovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity.
Not available
S-EPMC7025388 | biostudies-literature
UnknownForce sensing by mechanical extension of the Src family kinase substrate p130Cas.
Not available
S-EPMC2746973 | biostudies-literature
UnknownTranslation, validation and psychometric properties of Effort-Reward Imbalance questionnaire among nurses in Vietnam.
Not available
S-EPMC8855701 | biostudies-literature
TranscriptomicsTranscription profiling of human coronary arteries from patients with and without collateral artery vessels to identify novel markers of coronary collateralization
Evaluation of transcriptional regulation in Coronary artery disease patients with and without collateral artery vessels.
ORGANISM(S): Homo sapiens 
2006-03-10 | E-MEXP-564 | biostudies-arrayexpress
UnknownCorrelation of Performance Status and Neutrophil-Lymphocyte Ratio with Efficacy in Radioiodine-Refractory Differentiated Thyroid Cancer Treated with Lenvatinib.
Not available
S-EPMC8377516 | biostudies-literature
UnknownOverall survival analysis of EXAM, a phase III trial of cabozantinib in patients with radiographically progressive medullary thyroid carcinoma.
Not available
S-EPMC5834040 | biostudies-literature
UnknownRisk of HPV-16/18 Infections and Associated Cervical Abnormalities in Women Seropositive for Naturally Acquired Antibodies: Pooled Analysis Based on Control Arms of Two Large Clinical Trials.
Not available
S-EPMC5989610 | biostudies-literature
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