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MetabolomicsL-serine enables reducing the virulence of Acinetobacter baumannii and modulating the SIRT1 pathway to eliminate the pathogen

The emergence of high-virulent Acinetobacter baumannii strains increases the mortality of patients and seriously affects their prognosis, which motivates us to explore novel ways to control such infections. In this study, gas chromatography-mass spectrometry was adopted to explore the me...

2024-01-18 | MTBLS8966 | MetaboLights
TranscriptomicsGene Expression data from Pdx-1CreAPC+/LP53L/L pancreatic ductal adenocarcinoma (PDAC) cells versus Pdx-1CreP53L/L normal pancreatic ductal cells
Analysis of primary PDAC cells established from Pdx-1CreAPCL/+p53L/L and Pdx-1Crep53L/L mice. APC haploinsufficiency combined with P53 loss in the pancreas drives MCN progression in mice. Results provide insight into molecular mechanisms invloved in the MCN formation of Pdx-1Cre APCL/+P53L/L mice....
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-61894 | biostudies-arrayexpress
UnknownSimultaneous Electrochemical Sensing of Indole-3-Acetic Acid and Salicylic Acid on Poly(L-Proline) Nanoparticles-Carbon Dots-Multiwalled Carbon Nanotubes Composite-Modified Electrode.
Not available
S-EPMC8949798 | biostudies-literature
TranscriptomicsStilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity
Genome wide DNA methylation profiling of human breast cancer cell lines, lowly invasive MCF10CA1h and highly invasive MCF10CA1a, treated with vehicle control (ethanol) and with RSV (resveratrol). The Illumina Infinium 450K Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profil...
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-80794 | biostudies-arrayexpress
GenomicsA high-resolution view of transcription and chromatin states across distinct metabolic states in budding yeast
Under continuous, glucose-limited conditions, budding yeast exhibit robust metabolic cycles associated with major oscillations of gene expression and metabolic state. However, how such fluctuations might be coordinately linked to changes in chromatin status is less well understood. Here, we examine ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-31 | E-GEOD-52339 | biostudies-arrayexpress
TranscriptomicsMurine Pancreatic Cancer Cells: KLF10 wild type vs KLF10 knockout
Transcriptional profiling of mouse pancreatic cancer cells comparing Pdx-1Cre LSL-KrasG12D P53L/L cells with Pdx-1Cre LSL-KrasG12D KLF10L/L P53L/L cells, and to determine the effects of KLF10 deficiency on murine PDAC gene expression. Two-condition experiment, Pdx-1Cre LSL-KrasG12D P53L/L cells vs. ...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-85521 | biostudies-arrayexpress
UnknownResequencing and SNP discovery of Amur ide (Leuciscus waleckii) provides insights into local adaptations to extreme environments.
Not available
S-EPMC7930030 | biostudies-literature
TranscriptomicsA genome-wide genetic interaction screen reveals metabolic roles of human histone deacetylase 1
Dynamic acetylation of metabolic proteins has emerged as a ubiquitous post-translational modification of human metabolic proteins. However, the corresponding modifying enzymes and the functions of the modification await exploration. Using a genome-wide synthetic lethality screen, we constructed a ge...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-29662 | biostudies-arrayexpress
UnknownAssociations between dietary coenzyme Q10 intake and lipid profiles in adults: a national cross-sectional study.
Not available
S-EPMC11600311 | biostudies-literature
UnknownPost-treatment serum triglyceride: An effective biomarker for body fat mass and overall survival in esophageal squamous cell cancer patients treated with chemoradiotherapy.
Not available
S-EPMC9755343 | biostudies-literature
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