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TranscriptomicsLCM-based microarray analysis of neuronal vulnerability in the mouse model of Sanfilippo syndrome (MPSIIIB)
Sanfilippo syndrome type B (MPS III B) is an autosomal recessive, neurodegenerative disease of children, characterized by profound mental retardation and dementia. The primary cause is mutation in the NAGLU gene, resulting in deficiency of N-acetylglucosaminidase and lysosomal accumulation of hepara...
ORGANISM(S): Mus musculus 
2009-04-22 | E-GEOD-15758 | biostudies-arrayexpress
TranscriptomicsLCM-based microarray analysis of TAU-P301L and SOD1-G93A motor neurons and surrounding glial cells
Familial amyotrophic lateral sclerosis (ALS) represents about 10% of ALS cases. In about 20% of familial ALS patients, a mutation in superoxide dismutase-1 (SOD1) can be found. The ubiquitous SOD1 protein converts superoxide radical anions to oxygen and hydrogen peroxide. Patients with familial ALS ...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-22482 | biostudies-arrayexpress
TranscriptomicsRat model of MTLE: Animals with epilepsy vs animals without epilepsy (Agilent)
Neither the molecular basis of the pathologic tendency of neuronal circuits to generate spontaneous seizures (epileptogenicity) nor anti-epileptogenic mechanisms that maintain a seizure-free state are well understood. Here, we performed transcriptomic analysis in the intrahippocampal kainate model o...
ORGANISM(S): Rattus norvegicus 
2011-02-13 | E-GEOD-27015 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain samples from human and chimpanzee subjects
The origin of humans was accompanied by the emergence of new behavioral and cognitive functions, including language and specialized forms of abstract representation. However, the molecular foundations of these human capabilities are poorly understood. Because of the extensive similarity between huma...
ORGANISM(S): Pan troglodytes 
2007-10-31 | E-GEOD-7540 | biostudies-arrayexpress
TranscriptomicsRat model of MTLE: Animals with epilepsy vs animals without epilepsy (codelink)
Neither the molecular basis of the pathologic tendency of neuronal circuits to generate spontaneous seizures (epileptogenicity) nor anti-epileptogenic mechanisms that maintain a seizure-free state are well understood. Here, we performed transcriptomic analysis in the intrahippocampal kainate model o...
ORGANISM(S): Rattus norvegicus 
2011-02-13 | E-GEOD-27166 | biostudies-arrayexpress
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