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ProteomicsInteractions of CDK19 with MED12 and cyclin-C assessed by chemical cross-linking mass spectrometry
Chemical cross-linking coupled to mass spectrometry was used to study binary and ternary complexes involving cyclin-dependent kinase 19 (CDK19), cyclin-C, and an N-terminal fragment of subunit 12 of the Mediator complex (MED12 1-100). Cross-linking was performed using disuccinimidyl suberate (DSS). ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-18 | PXD019251 | Pride
Chemical cross-linking  dss  structural proteomics  mediator complex  kinase 
TranscriptomicsThe structure of human Argonaute-2 in complex with miR-20a
Argonaute proteins lie at the heart of the RNA-Induced Silencing Complex (RISC), wherein they use small RNA guides to recognize targets. Some Argonaute proteins can directly cleave their targets, whereas others recruit co-factors to repress independently of “slicing.” Prior studies established the a...
ORGANISM(S): Spodoptera frugiperda 
2012-05-12 | E-GEOD-37931 | biostudies-arrayexpress
ProteomicsA precisely positioned MED12 activation helix stimulates CDK8 kinase activity
Chemical cross-linking coupled to mass spectrometry was used to study binary and ternary complexes involving cyclin-dependent kinase 8 (CDK8), cyclin-C, and subunit 12 of the Mediator complex (MED12). Cross-linking was performed using different cross-linking chemistries: (1) disuccinimidyl suberate ...
ORGANISM(S): Homo sapiens (Human) 
2020-01-16 | PXD015394 | Pride
Chemical cross-linking  dss  pdh  dmtmm  structural proteomics  mediator complex  kinase 
UnknownEffectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations: the OPTIPARK open-label study.
Not available
S-EPMC7055125 | biostudies-literature
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