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TranscriptomicsStreptococcus pneumoniae in a biofilm are hyper-adhesive, avirulent, and when used as a killed whole-cell vaccine confers protection against lethal challenge
For Streptococcus pneumoniae, biofilms have been suggested to promote long-term colonization of the nasopharynx and contribute to the pathology of recurrent middle ear infections. To date numerous studies have investigated the contribution of specific genetic determinants for the development of pneu...
ORGANISM(S): Streptococcus pneumoniae 
2013-04-01 | E-GEOD-26976 | biostudies-arrayexpress
ProteomicsMechanistic insight into the role of enzyme mevalonate kinase by a natural fatty acid -mediated killing of Leishmania donovani
We evaluated the anti-leishmanial efficacy of different saturated medium-chain fatty acids (FAs, C8-C18) where FA containing C8 chain, caprylic acid (CA), was found to be most potent against Leishmania donovani, the causative agent for visceral leishmaniasis (VL). Different analogs of CA with C8 cha...
ORGANISM(S): Leishmania donovani BPK282A1 
2022-10-14 | PXD034560 | Pride
Proteomics Ergosterol depletion Mevalonate kinase Competitive inhibition Caprylic acid Visceral leishmaniasis 
UnknownSequential one-pot synthesis of bis(indolyl)glyoxylamides: Evaluation of antibacterial and anticancer activities.
Not available
S-EPMC4899133 | biostudies-literature
TranscriptomicsTranscription profiling of mouse multiple myeloma tumors and splenic B cells from transgenics overexpressing XBP-1s
Multiple myeloma (MM) evolves from highly prevalent premalignant condition termed Monoclonal Gammopathy of Undetermined Significance (MGUS). We report an MGUS-MM phenotype arising in transgenic mice with Emu-directed expression of the unfolded protein/ER stress response and plasma cell development ...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-6980 | biostudies-arrayexpress
UnknownInsect-pathogen crosstalk and the cellular-molecular mechanisms of insect immunity: uncovering the underlying signaling pathways and immune regulatory function of non-coding RNAs.
Not available
S-EPMC10491481 | biostudies-literature
TranscriptomicsMicroarray analysis to identify the molecular mechanisms whereby pDCs confer growth and drug resistance in MM cells
Multiple Myeloma (MM) remains incurable despite novel therapies, suggesting the need for further identification of factors mediating tumorigenesis and drug resistance. We performed microarray analysis to identify the molecular mechanisms whereby pDCs confer growth and drug resistance in MM cells. Co...
ORGANISM(S): Homo sapiens 
2009-07-31 | E-GEOD-17407 | biostudies-arrayexpress
TranscriptomicsInducible expression of macrolide efflux in Streptococcus pneumoniae is controlled by transcriptional attenuation of the mef(E)/mel operon
Macrolide resistance, increasingly identified in Streptococcus pneumoniae and a wide range of other Gram-positive bacteria, is often due to efflux pumps encoded by the mef/mel(msr) operon found on discrete mobile genetic elements. The regulation of mef/mel(msr) in these elements is not well understo...
ORGANISM(S): Streptococcus pneumoniae 
2014-02-01 | E-GEOD-54176 | biostudies-arrayexpress
TranscriptomicsNeuraminidase-exposed galactose promotes Streptococcus pneumoniae biofilm formation during colonization
Galactose promotes pneumococcal biofilms in vivo 15 mRNA profiles of Streptococcus pneumoniae samples that were grown under different conditions were generated using deep sequencing.
ORGANISM(S): Streptococcus pneumoniae 
2016-08-04 | E-GEOD-85196 | biostudies-arrayexpress
Genomicsena-DATASET-GoT2D/T2D-GENES-09-07-2016-02:03:47:226-1135 - samples
The GoT2D study includes ~2800 samples, half T2D cases and half T2D controls, of Northern European ancestry sequenced over 3 three technologies: deep whole exome sequencing, low-pass (4x) whole genome sequencing, and OMNI 2.5M genotyping. Samples were ascertained to be phenotypically "extreme" (e.g....
EGAD00001002247 | EGA
GenomicsImputation analysis file
This data set includes the following summary level data file used for the imputation data: imputation.sv.assoc.txt: results from single variant association analysis in imputed samples
EGAD00010001184 | EGA
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