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TranscriptomicsDysregulation of pathways involved in the processing of cancer and microenvironment information in MCA+TPA transformed C3H/10T1/2 cells
The two-stage cell transformation assay is an in vitro model cell culture system to identify the ability of chemicals to act as initiators or promoters of cell transforma- tion and also to study the cellular and molecular mechanisms of chemically induced morphological and neoplastic cell transformat...
ORGANISM(S): Mus musculus 
2013-04-26 | E-GEOD-41142 | biostudies-arrayexpress
TranscriptomicsDiethyl maleate inhibits MCA+TPA transformed cell growth via modulation of GSH, MAPK, and cancer pathways
Murine or human cancer cells have high glutathione levels. Depletion of the elevated GSH inhibits proliferation of cancer cells. Molecular basis for this observation is little understood. In an attempt to find out the underlying mechanism, we reproduced these effects in transformed C3H10T1/2 and BAL...
ORGANISM(S): Mus musculus 
2014-06-02 | E-GEOD-44650 | biostudies-arrayexpress
TranscriptomicsLipoic acid prevents Cr6+ induced cell transformation and the associated genomic dysregulation.
Investigation of the transcription profile of cells transformed by Cr6+ in vivo was undertaken. The objective was to elucidate genomic changes underlying the mechanism of action of the carcinogenic dose of Cr6+and their prevention using metabolic antioxidant Lipoic acid (LA). Cr6+ was administered i...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-41419 | biostudies-arrayexpress
TranscriptomicsERK activation, gene dysregulations and cell transformation at submicromolar doses of Cr6+ in C3H10T1/2 and BALB/c 3T3 cells: interaction with Lipoic acid
The molecular mechanism of Cr6+ carcinogenicity is not well understood. Studies advocate a key involvement of the altered cytogenomics and dysregulated pathways in Cr6+ toxicity. However, the dissimilarity in expression of genes and pathways in cells transformed by Cr6+ has led us to supplement more...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-43156 | biostudies-arrayexpress
UnknownHigh power surface emitting terahertz laser with hybrid second- and fourth-order Bragg gratings.
Not available
S-EPMC5895695 | biostudies-literature
TranscriptomicsGenome-wide gene expression analysis for target genes to differentiate patients with intestinal tuberculosis and Crohn’s disease
This study aimed at genome-wide gene expression analysis of colonic biopsies from confirmed cases of intestinal tuberculosis (ITB) and Crohn's disease (CD) in comparison to controls. Further, to evaluate the role of T regulatory cells, Foxp3 mRNA expression was quantified in serum as well as colonic...
ORGANISM(S): Homo sapiens 
2011-01-04 | E-GEOD-26305 | biostudies-arrayexpress
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