Model destription:
The model describes the stochastic dynamics of two variables, protein and mRNA of a gene with constitutive expression.
Publication:
A New Efficient Approach to Fit Stochastic Models on the Basis of High-throughput Experimental Data Using a Model of IRF7 Gene Expression as Case S...
Model destription:
The model describes the dynamics of murine IRF7 gene expression upon IFN stimulation. The present model comprises known key components and feedback mechanisms. The overall system describes the active IRF7 promoter (Pa) by the binding of IRF7 dimer and ISGF3 to the DNA binding si...
A group of gram positive bacteria that share the characteristic of fermenting hexose sugars to lactic acid are generally referred to as lactic acid bacteria (LAB). Enterococcus faecalis is one of the widely studied LABs due to a multiutude of reasons. On the one hand, it plays an important role in d...
Genome-scale models represent the link between an organism's genetic information and experimentally observable biological phenotypes. They facilitate metabolic engineering and the discovery of network properties such as the identification of novel drug targets. Most commonly, metabolite consumption ...
Genome-scale models represent the link between an organism's genetic information and experimentally observable biological phenotypes. They facilitate metabolic engineering and the discovery of network properties such as the identification of novel drug targets. Most commonly, metabolite consumption ...
This model is from the article:
Dynamics and feedback loops in the transforming growth factor β signaling pathway.
Wegner K, Bachmann A, Schad JU, Lucarelli P, Sahle S, Nickel P, Meyer C, Klingmüller U, Dooley S, Kummer U. Biophys Chem.
...
Maier2022 - Stochastic Dynamics of Type I Interferon Responses
Our study aims to determine whether and how biochemical noise affects the information transduced in the JAK-STAT signaling pathway and investigate the transition between basal and activated state. To this end, we studied the stochastic ...
Olsen2003_neutrophil_oscillatory_metabolism
This model is described in the article:
A model of the oscillatory
metabolism of activated neutrophils.
Olsen LF, Kummer U, Kindzelskii AL,
Petty HR.
Biophys. J. 2003 Jan; 84(1):
69-81
Abstract:
We present a two-compartmen...
