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ProteomicsKAT5-mediated acetylation of PC4 facilitates DNA repair by promoting chromatin reorganization
Human positive coactivator 4 (PC4), is a highly abundant non-histone chromatin protein involved in diverse cellular processes, including transcription regulation, genome organization, autophagy, B-cell differentiation, neurogenesis, DNA repair, etc. Most PC4 is phosphorylated in cells, which interac...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD059878 | Pride
Non-histone chromatin protein Lysine acetyltransferases (kats) Positive coactivator 4 (pc4) Dna damage Atomic force microscopy (afm) 
ProteomicsKAT5-mediated acetylation of PC4 facilitates DNA repair by promoting chromatin reorganization
Human positive coactivator 4 (PC4), is a highly abundant non-histone chromatin protein involved in diverse cellular processes, including transcription regulation, genome organization, autophagy, B-cell differentiation, neurogenesis, DNA repair, etc. Most PC4 is phosphorylated in cells, which interac...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD058855 | Pride
Non-histone chromatin protein Lysine acetyltransferases (kats) Positive coactivator 4 (pc4) Dna damage Atomic force microscopy (afm) 
TranscriptomicsSpecific inhibition of p300-HAT alters Global Gene Expression and Repress HIV replication
Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer, neurodegenaration, asthma, diabetes, AIDS and cardiac hypertrophy. We describe the synthesis and characte...
ORGANISM(S): Homo sapiens 
2010-06-11 | E-GEOD-7818 | biostudies-arrayexpress
UnknownSERS and MD simulation studies of a kinase inhibitor demonstrate the emergence of a potential drug discovery tool.
Not available
S-EPMC4115535 | biostudies-literature
UnknownPositive coactivator PC4 shows dynamic nucleolar distribution required for rDNA transcription and protein synthesis.
Not available
S-EPMC12167574 | biostudies-literature
UnknownReinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator.
Not available
S-EPMC6220301 | biostudies-literature
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