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TranscriptomicsMicroarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
Xenograft models remain a cornerstone technology in the development of anti-cancer agents. The ability of immunocompromised rodents to support the growth of human tumors provides an invaluable transition between in vitro testing and clinical trials. Therefore, approaches to improve model selection a...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-48433 | biostudies-arrayexpress
TranscriptomicsDetecting novel genes with sparse arrays
Species-specific genes play an important role in defining the phenotype of an organism. However, current gene prediction methods can only efficiently find genes that share features such as sequence similarity or general sequence characteristics with previously known genes. Novel sequencing methods a...
ORGANISM(S): Hypocrea jecorina 
2010-08-12 | E-GEOD-12960 | biostudies-arrayexpress
UnknownEpigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes.
Not available
S-EPMC4375075 | biostudies-literature
UnknownThe Histone Methyltransferase MLL1 Directs Macrophage-Mediated Inflammation in Wound Healing and Is Altered in a Murine Model of Obesity and Type 2 Diabetes.
Not available
S-EPMC5566299 | biostudies-literature
TranscriptomicsTranscription profiling by array of Arabidopsis plants after innoculation with isogenic Pseudomonas syringaie strains expressing one of four different avr genes
Gene expression profiles of a single Arabidopsis genotype (Col-0) in response to isogenic Pseudomonas syringae strains expressing one of four different cloned avr genes was studied (avrRpt2, avrRpm1, avrPphB, avrRps4; responses mediated by the R genes RPS2, RPM1, RPS5 and RPS4 ).
ORGANISM(S): Arabidopsis thaliana 
2008-02-29 | E-MEXP-1480 | biostudies-arrayexpress
UnknownSepsis Induces Prolonged Epigenetic Modifications in Bone Marrow and Peripheral Macrophages Impairing Inflammation and Wound Healing.
Not available
S-EPMC6818743 | biostudies-literature
TranscriptomicsEvaluating cross-hybridization of murine cDNA to the Affymetrix Human Genome U133 Plus 2.0 chipset
Transcriptomic studies of human tumor xenografts are complicated by the presence of murine cellular mRNA. As such, it is useful to know the extent to which mouse mRNA cross-hybridizes to any given array platform. In this study, murine cDNA samples from diverse sources were hybridized to Affymetrix H...
ORGANISM(S): Mus musculus 
2013-07-31 | E-GEOD-49353 | biostudies-arrayexpress
TranscriptomicsA missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency (Family A)
Affymetrix 6.0 SNP data for genome-wide linkage scans of a consanguineous Kuwaiti family with a combined immunodeficiency Peripheral blood or saliva were used for patients who had no history of hematopoietic stem cell transplant (HSCT). Fibroblasts cell lines were used as a source of DNA for individ...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-75314 | biostudies-arrayexpress
TranscriptomicsA missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency (Family B)
Affymetrix 6.0 SNP data for haplotype comparison of patients from two different families sharing the same homozygous mutation in TFRC, to determine if the families were related to each other Peripheral blood was used for patients who had no history of hematopoietic stem cell transplant (HSCT). Fibro...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-75349 | biostudies-arrayexpress
UnknownComparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Not available
S-EPMC10203973 | biostudies-literature
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