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A precisely positioned MED12 activation helix stimulates CDK8 kinase activity

Chemical cross-linking coupled to mass spectrometry was used to study binary and ternary complexes involving cyclin-dependent kinase 8 (CDK8), cyclin-C, and subunit 12 of the Mediator complex (MED12). Cross-linking was performed using different cross-linking chemistries: (1) disuccinimidyl suberate ...

ORGANISM(S): Homo sapiens (Human)

2020-01-16 | PXD015394 | Pride