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TranscriptomicsCharacterization of the piRNA Complex from Rat Testes
This data series contains the sequences and read counts of Piwi-interacting RNAs and other small RNAs from mouse and rat testes extracts. In a search for different classes of small RNAs that might be involved in transcriptional gene silencing, we encountered a novel class of small RNAs within mamma...
ORGANISM(S): Mus musculus 
2006-07-02 | E-GEOD-5026 | biostudies-arrayexpress
TranscriptomicsAnalysis of small RNAs in piRNA pathway mutant mouse testes
Piwi-interacting RNAs are 25-32 nt small RNAs bound to Piwi proteins. To know the steps where factors involved in the piRNA biogenesis (MILI, MIWI2, ZUC (MitoPLD), MVH) work, we sequenced small RNAs from mutant mouse testes and analyzed piRNAs. Examination of small RNAs in testes of mutant mouse
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20327 | biostudies-arrayexpress
UnknownBlood DNA virome associates with autoimmune diseases and COVID-19.
Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, in...
S-EPMC11735405 | biostudies-literature
UnknownSingle-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity.
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 coronavirus disease 2019 (COVID-19) patie...
S-EPMC10181941 | biostudies-literature
UnknownThe whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force.
Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individual...
S-EPMC9395416 | biostudies-literature
UnknownDeciphering state-dependent immune features from multi-layer omics data at single-cell resolution.
Current molecular quantitative trait locus catalogs are mostly at bulk resolution and centered on Europeans. Here, we constructed an immune cell atlas with single-cell transcriptomics of >1.5 million peripheral blood mononuclear cells, host genetics, plasma proteomics and gut metagenomics from 235 J...
S-EPMC12339405 | biostudies-literature
UnknownDOCK2 is involved in the host genetics and biology of severe COVID-19.
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge1-5. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3,289 unaffe...
S-EPMC9492544 | biostudies-literature
UnknownCharacteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force.

Background

We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant.

Methods

We used secondary data from a database and performed ...
S-EPMC9744033 | biostudies-literature
UnknownQuantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues.
Several X-linked genes escape from X chromosome inactivation (XCI), while differences in escape across cell types and tissues are still poorly characterized. Here, we developed scLinaX for directly quantifying relative gene expression from the inactivated X chromosome with droplet-based single-cell ...
S-EPMC11406184 | biostudies-literature
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