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GenomicsHistone acetylation regulates intracellular pH
Differences in global levels of histone acetylation occur in normal and cancer cells, although the reason cells regulate these levels has remained unclear. Here we demonstrate a role for histone acetylation in regulating intracellular pH (pHi). As pHi decreases, histones are globally deacetylated by...
ORGANISM(S): Homo sapiens 
2012-11-04 | E-GEOD-40114 | biostudies-arrayexpress
GenomicsGenome-wide binding map of the HIV Tat protein to the human genome (ChIP-Seq)
The HIV-1 Trans-Activator of Transcription (Tat) protein binds to multiple host cellular factors and greatly enhances the level of transcription of the HIV genome. Here, we report the genome-wide binding map of Tat to the human genome in Jurkat T cells (Jurkat-Tat cells) using chromatin immunopreci...
ORGANISM(S): Homo sapiens 
2011-11-06 | E-GEOD-30738 | biostudies-arrayexpress
TranscriptomicsA unique epigenetic signature is associated with active DNA replication loci in human embryonic stem cells
The cellular epigenetic landscape changes as pluripotent stem cells differentiate to somatic cells or when differentiated cells transform to a cancerous state. These epigenetic changes are commonly correlated with differences in gene expression. Whether active DNA replication is also associated with...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-43152 | biostudies-arrayexpress
TranscriptomicsExpression profiles and ChIP on chip genomewide experiments with dl1500 virus (expressing WT small e1a).
Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses a...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12045 | biostudies-arrayexpress
TranscriptomicsExpression profiles and ChIP on chip genomewide experiments with R2G mutant virus
Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses a...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12046 | biostudies-arrayexpress
TranscriptomicsExpression profiles and ChIP on chip genomewide experiments with deltaCR2 mutant virus
Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses a...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12047 | biostudies-arrayexpress
TranscriptomicsProfiles and ChIP on chip experiments with dl1500 virus (expressing WT small e1a), R2G and deltaCR2 mutant viruses
Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses a...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-12543 | biostudies-arrayexpress
GenomicsScl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers [ChIP-seq]
Scl/Tal1 confers hemogenic competence and prevents cardiomyogenesis in embryonic endothelium. Here we show that Scl both directly activates a broad gene regulatory network required for hematopoietic stem/progenitor cell (HS/PC) development, and represses transcriptional regulators required for cardi...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-47082 | biostudies-arrayexpress
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