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ProteomicsInhibition of T cell activation and function by the CIN85 adaptor protein
CIN85 is ubiquitously expressed adaptor protein. In T cells, CIN85 is recruited to the TCR signaling complex and inhibit TCR signaling. To reveal the molecular function of CIN85-mediated inhibition, we performed Flag-CIN85 (CIN85dA) immuno-precipitation and identified the binding proteins. As a nega...
ORGANISM(S): Mus Musculus (mouse) 
2019-01-16 | PXD012369 | JPOST Repository
TranscriptomicsThe Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis
Although CD4 T cell senescence plays an important role in immunosenescence, the mechanism behind this process remains unclear. Here we show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype...
ORGANISM(S): Mus musculus 
2014-03-27 | E-GEOD-49968 | biostudies-arrayexpress
TranscriptomicsGene expressions of memory B cells and other type of B cells
To obtain insight into the genetic basis of the increase of functional activity of memory B cells over time, we compared the gene expression profiles of day 7 and day 40 NP-specific/IgG1 memory B cells, GC B cells and plasma cells in immunized WT mice and naïve B cells, before and after activation i...
ORGANISM(S): Mus musculus 
2012-09-21 | E-GEOD-11961 | biostudies-arrayexpress
TranscriptomicsRegulation of B cell early development by CNOT3
The CCR4-NOT complex, bearing poly(A) deadenylation activity, is a highly conserved regulator that is involved in biological control; however its action mechanisms and physiological targets remain unclear. Using genetic deletion of the CNOT3 subunit of this complex in early B cell progenitors, we sh...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-64455 | biostudies-arrayexpress
TranscriptomicsThe transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program
Mature lymphoid cells express the transcriptional repressor Bach2, which imposes regulation on humoral and cellular immunity. Here we found critical roles for Bach2 in the development of cells of the B lineage, commencing from the common lymphoid progenitor (CLP) stage, with Bach1 as an auxiliary. O...
ORGANISM(S): Mus musculus 
2014-10-26 | E-GEOD-61409 | biostudies-arrayexpress
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