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TranscriptomicsDetailed transcriptome atlas of the pancreatic beta cell
The aim of the present study was to explore the transcriptome of pancreatic islets and, based on this information, to prepare a comprehensive and open access inventory of insulin-producing ?-cell gene expression, the beta-Cell Gene Atlas (BCGA). INS-1 cells, primary rat beta-cells (>87% beta-cells) ...
ORGANISM(S): Rattus norvegicus 
2008-12-31 | E-GEOD-13381 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human islets after in vitro expansion.
Pancreatic islet transplantation as a cure for type 1 diabetes (T1D) cannot be scaled up due to a scarcity of human pancreas donors. In vitro expansion of beta cells from mature human pancreatic islets provides an alternative source of insulin-producing cells. The exact nature of the expanded cells ...
ORGANISM(S): Homo sapiens 
2009-08-07 | E-GEOD-15543 | biostudies-arrayexpress
TranscriptomicsRat insulin-producing INS-1E exposed to cytokines IL-1β and IFN-γ
In the context of T1 Diabetes, pro-inflammatory cytokines IL-1β and IFN-γ are known to contribute to β-cell apoptosis; The measurement of mRNA expression following β-cell exposure to these cytokines gives a picture of the changes in gene expression characterizing the path to β-cell dysfunction and d...
ORGANISM(S): Rattus norvegicus 
2013-12-19 | E-GEOD-53453 | biostudies-arrayexpress
TranscriptomicsHuman islets exposed to cytokines IL-1β and IFN-γ
In the context of T1 Diabetes, pro-inflammatory cytokines IL-1β and IFN-γ are known to contribute to β-cell apoptosis; The measurement of mRNA expression following β-cell exposure to these cytokines gives a picture of the changes in gene expression characterizing the path to β-cell dysfunction and d...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-53454 | biostudies-arrayexpress
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