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TranscriptomicsTranscription profiling by array of mouse neocortical neural precursor cells incubated with Wnt3a for 0,3,6 and 12 hours
Microarray analysis for the identification of the downstream targets of Wnt signaling in the developing neocortex.
ORGANISM(S): Mus musculus 
2010-02-26 | E-TABM-923 | biostudies-arrayexpress
GenomicsThe Menin–Bach2 axis is critical for regulating CD4 T cell senescence and homeostasis
Although CD4 T cell senescence plays an important role in immunosenescence, the mechanisms remain unclear. We found that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, accompanied by the senescence-associated secretory phenotype (SASP) after antigenic stimulati...
ORGANISM(S): Mus musculus 
2014-03-27 | E-GEOD-53831 | biostudies-arrayexpress
TranscriptomicsIdentification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGFbeta [Agilent]
IL-4 plays an important role in the induction of Th2 and Th9 cells as well as in the inhibition of Th1 cell generation. We herein show that a combination of IL-4 and TGFbeta augment the development of Th1 cells that express CD103 (CD103+ Th1 cells) if IFNgamma is present. The T-box containing tran...
ORGANISM(S): Mus musculus 
2012-03-17 | E-GEOD-36554 | biostudies-arrayexpress
TranscriptomicsIdentification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGFbeta [Affymetrix]
IL-4 plays an important role in the induction of Th2 and Th9 cells as well as in the inhibition of Th1 cell generation. We herein show that a combination of IL-4 and TGFbeta augment the development of Th1 cells that express CD103 (CD103+ Th1 cells) if IFNgamma is present. The T-box containing tran...
ORGANISM(S): Mus musculus 
2012-03-17 | E-GEOD-36520 | biostudies-arrayexpress
TranscriptomicsA novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus
IL-5 is a key cytokine that plays an important role in the development of pathological conditions in chronic allergic inflammation. Identification of a strategy to inhibit IL-5 production is important for establishment of new therapies for allergic inflammation. We found that SH-2251, a novel thio...
ORGANISM(S): Mus musculus 
2013-04-30 | E-GEOD-42131 | biostudies-arrayexpress
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