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UnknownThree independent mutations in the TSC2 gene in a family with tuberous sclerosis.
Not available
S-EPMC2874752 | biostudies-literature
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
UnknownMammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Not available
S-EPMC4471336 | biostudies-literature
UnknownThe Impact of Smoking and TP53 Mutations in Lung Adenocarcinoma Patients with Targetable Mutations-The Lung Cancer Mutation Consortium (LCMC2).
Not available
S-EPMC7008001 | biostudies-literature
UnknownNeoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial.
Not available
S-EPMC9556329 | biostudies-literature
UnknownUsing multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs.
Not available
S-EPMC4163053 | biostudies-literature
TranscriptomicsLKB1 modulates lung cancer differentiation and metastasis
Inherited mutation in LKB1 results in the Peutz-Jeghers syndrome (PJS), characterized by intestinal hamartomas and a modestly increased frequency of gastrointestinal and breast cancer1. Somatic inactivation of LKB1 occurs in human lung adenocarcinoma2-4, but its tumor suppressor role in this tissue ...
ORGANISM(S): Homo sapiens 
2007-08-28 | E-GEOD-6135 | biostudies-arrayexpress
UnknownAncestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors.
Not available
S-EPMC9559771 | biostudies-literature
GenomicsSMG
Severe malaria cases from Gambia
EGAD00000000018 | EGA
GenomicsCBC
Cord blood control samples from Gambia
EGAD00000000017 | EGA
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