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TranscriptomicsGene expression profiling of thymocytes from conditional knock-out mice (FoxN1-Cre mediated KO of Gpr177)
Comparative gene expression profiling of thymocytes at the DP, CD4 SP and CD8 SP stage derived from FoxN1-Gpr177 mice (FoxN1-Cre mediated deletion of (Exon3 of) Gpr177/Wtls) or C57Bl/6N mice as comparison. Objective was to test the influence of TEC-secreted Wnt ligands on the transcriptome of thymoc...
ORGANISM(S): Mus musculus 
2015-11-01 | E-GEOD-69766 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the TEC-specific Hipk2 gene knockout in mouse medullary thymic epithelial cells (mTECs)
Analysis of the role of Hipk2 in regulating gene expression in medullary thymic epithelial cells. The whole genome gene signatures of purified mTEC subsets (CD80 low, CD80 high) from TEC-specific Hipk2 knockout mice were compared to mating wildtype control mice (floxed, Cre-). Results provide the up...
ORGANISM(S): Mus musculus 
2015-01-05 | E-GEOD-63432 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of TRA (tissue restricted antigen)-specific co-expression groups in mouse medullary thymic epithelial cells (mTECs)
Analysis of gene co-expression patterns in TRA-specific medullary thymic epithelial cell (mTEC) subsets. The whole genome gene signatures of purified mTEC subsets respectively positive for the TRAs Gp2, Pdpn, Cea1, Gad1, Ins2, Tspan8 were compared to their corresponding TRA-negative mTEC subset cont...
ORGANISM(S): Mus musculus 
2015-10-28 | E-GEOD-69435 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse thymic stromal cells from 6-12 week old wild type (C57BL/6) and Aire knock-outs (mixed background)
Gene expression in different thymic stromal cells and subsets thereof was analyzed in 6-12 week old wild type (C57BL/6) and Aire knock-out (mixed background) mice. Thymic stromal cells were purified by sequential enzymatic digestion (collagenase, collagenase/dispase and trypsin) followed by gradient...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-2585 | biostudies-arrayexpress
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