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ProteomicsPannexin 1 interactome in Rhabdomyosarcoma
We have recently reported the down-regulation of pannexin 1 (PANX1) levels in rhabdomyosarcoma (RMS) and that restoration of its expression inhibits the progression of embryonal (eRMS) and alveolar (aRMS) rhabdomyosarcoma in vitro and in vivo. While we have shown that this PANX1-mediated inhibition ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-30 | MSV000084867 | MassIVE
GenomicsGenome-wide map of RNA polymerase II, NELF, and DSIF in HeLa cells
Most metazoan promoters have RNA polymerase II (Pol II) paused slightly downstream of the transcription start site by NELF and DSIF. This pausing keeps these promoters available for rapid induction by P-TEFb, whose activity causes NELF to dissociate and Pol II and DSIF to elongate on the gene. ChIP-...
ORGANISM(S): Homo sapiens 
2014-02-01 | E-GEOD-53008 | biostudies-arrayexpress
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
TranscriptomicsTranscriptional responses of Mycobacterium tuberculosis to lung surfactant
This study uses microarray analyses to examine gene expression profiles for Mycobacterium tuberculosis (Mtb) induced by exposure in vitro to bovine lung surfactant preparations that vary in apoprotein content: (i) whole lung surfactant (WLS) containing the complete mix of endogenous lipids and surfa...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-18 | E-GEOD-14005 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 36 individuals with autism spectrum disorder
To assess the clinical impact of splice-altering noncoding mutations in autism spectrum disorder (ASD), we used a deep learning framework (SpliceAI) to predict the splice-altering potential of de novo mutations in 3,953 individuals with ASD from the Simons Simplex Collection. To validate these predi...
ORGANISM(S): Homo sapiens 
2018-11-25 | E-MTAB-7351 | biostudies-arrayexpress
TranscriptomicsInfection of bone marrow derived macrophages with M. tuberculosis CDC1551
I infected 8 flasks of resting murine bone marrow derived macrophages with M. tuberculosis CDC1551. Individual samples of intracellular Mtb were collected at 2hr, and days 2,4,6,8,10,12, and 14 post-infection using the GTC (guanidine thiocyanate) method as previously published. A 2hr "no macr...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2012-07-11 | E-GEOD-35362 | biostudies-arrayexpress
UnknownLoss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction.
Not available
S-EPMC4331025 | biostudies-literature
UnknownSyntheMol-RL: a flexible reinforcement learning framework for designing easily synthesizable antibiotics
Not available
S-SCDT-10_1038-S44320-026-00206-9 | biostudies-other
TranscriptomicsMycobacterium tuberculosis Growth After Aerobic Expression of the DosR Regulon
Investigation of whole genome gene expression of M. tuberculosis strain H37Rv:deltaRv3133c::pEXNF-3133c following ectopic expression of a plasmid-borne copy of wildtype Rv3133c compared the same strain with Rv3133c uninduced. The M. tuberculosis H37Rv:deltaRv3133c was originally described in Mol Mic...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2012-01-31 | E-GEOD-33752 | biostudies-arrayexpress
ProteomicsS.cerevisiae - Whole organism, SC (Serikawa,mcp,2003)
abundance based on Spectral counting, Interaction consistency score: 1.6, Coverage: 20
ORGANISM(S): 4932 
2003-00-00 | 2226156413 | PAXDB
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