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MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine and human plasma quantitative L-arginine and methylarginines UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS685 | MetaboLights
TranscriptomicsTranscription profiling of mouse primary visual cortext from animals treated with monocular deprivation (MD), dark rearing and controls reveals binding protein of Insulin-like Growth Factor 1 is highly upregulated after MD
Two key paradigms for examining activity-dependent development of primary visual cortex (V1) involve either reduction of activity in both eyes via dark-rearing (DR) or imbalance of activity between the two eyes via monocular deprivation (MD).,Combining DNA microarray analysis with computational appr...
ORGANISM(S): Mus musculus 
2007-07-07 | E-GEOD-4537 | biostudies-arrayexpress
TranscriptomicsImpact of oxidative stress on ascorbate biosynthesis in Chlamydomonas via regulation of the VTC2 gene encoding a GDP-l-galactose phosphorylase
The l-galactose (Smirnoff-Wheeler) pathway represents the major route to l-ascorbic acid (vitamin C) biosynthesis in plants. Arabidopsis thaliana VTC2 and its paralogue VTC5 function as GDP-l-galactose phosphorylases converting GDP-l-galactose to l-galactose-1-P, thus catalyzing the first committed ...
ORGANISM(S): Chlamydomonas reinhardtii 
2012-05-02 | E-GEOD-34826 | biostudies-arrayexpress
ProteomicsD-score - D-score: a search engine independent MD-score
Processing of the dataset of synthetic phosphopeptides by Savitzki et al. (MCP, 2011) using multiple search engines. Establishment of the D-score: a search engine independent MD-score.
ORGANISM(S): Homo sapiens (Human) 
2013-01-23 | PXD000021 | Pride
Localization score Phosphorylation Synthetic peptides 
TranscriptomicsCotton Fiber Cells: Germplasm Line MD 52ne vs. Germplasm Line MD 90ne
Transcriptional profiling of cotton fiber cells from two cotton germplasm lines, MD 52ne and MD 90ne. Comparison of fiber cell transcription profiles is between the two germplasm lines and over a developmental time-course from 8 to 24 days post anthesis in four day intervals. Cotton plants grown in...
ORGANISM(S): Gossypium hirsutum 
2010-05-07 | E-GEOD-14388 | biostudies-arrayexpress
TranscriptomicsLipopolysaccharide (LPS) response in macrophages from MD-2-deficient mice
Lipid A (a hexaacylated 1,4 bis-phosphate) is a potent immune stimulant for TLR4/MD-2. Upon lipid A ligation, the TLR4/MD-2 complex dimerizes and initiates signal transduction. Historically, studies also suggested the existence of TLR4/MD-2-independent LPS signaling. Here we define the role of TLR4...
ORGANISM(S): Mus musculus 
2011-07-30 | E-GEOD-31067 | biostudies-arrayexpress
TranscriptomicsComparison of murine colonic mucosal gene expression between offspring born to mothers fed a methyl donor diet (MD) versus control at postnatal day 90 (P90).
BACKGROUND & AIMS: Inflammatory Bowel Diseases (IBD), including Crohnâ??s disease and ulcerative colitis, are chronic illnesses that are thought to develop secondary to a pathologic interaction between the immune system and the intestinal microflora that is manifested by the gut mucosa. IBD has been...
ORGANISM(S): Mus musculus 
2010-10-20 | E-GEOD-24354 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Bacillus subtilis wild type and yvcJ strains during the competence transition phase
Competence experiments were carried out in MD medium containing 10.7 g/l K2HPO4, 6 g/l KH2PO4, 1g/l trisodium citrate - 5H2O, 2% (w/v) glucose, 50 mg/l L-Trp, 11 mg/l ferric ammonium citrate, 2.5 g/l potassium aspartate et 3 mM MgS04. Wt and yvcJ strain were cultured in this medium until transition ...
ORGANISM(S): Bacillus subtilis 
2008-12-09 | E-MEXP-1471 | biostudies-arrayexpress
TranscriptomicsExpression analysis of MDA-MD-231 cells that express lysine racemase (lyr) when grown on D-Lysine versus L-Lysine
This experiment aimed to investigate whether cells that express the L-Lysine-producing enzyme lyr exhibit any mRNA changes when grown on precursor D-Lysine relative to L-Lysine.
ORGANISM(S): Homo sapiens 
2013-06-30 | GSE43895 | GEO
TranscriptomicsArabidopsis thaliana wild type mechanical damage (MD) vs herbivore wounding (HW)
Transcriptional profiling of Arabidopsis thaliana wild type (WT) comparing MD (mechanical damage) and HW (herbivore wounding). The differences in the biochemical responses to herbivory seen prompted us to search for less obvious differences between treatments using gene expression profiling. Biologi...
ORGANISM(S): Arabidopsis thaliana 
2012-09-18 | E-GEOD-40923 | biostudies-arrayexpress
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