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MetabolomicsAnalysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors

Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children and adults in endemic areas. Gene regulation of ETEC during growth in vitro and in vivo needs to be further evaluated, and here we describe the full transcriptome and metabolome of ETEC dur...

2022-07-15 | MTBLS3540 | MetaboLights
MetabolomicsRegional HNSCC metabolomics reveals widespread changes to one-carbon metabolism and S-adenosylmethionine metabolism across tumour core, tumour edge and adjacent non-tumour tissues

Cancer, including head and neck squamous cell carcinoma (HNSCC), induces changes to metabolism that drive the disease. Regional metabolomics can help to understand metabolic variation across the tumour including changes near the tumour core, where hypoxia is likely more pronounced. We apply ultra...

2026-06-03 | MTBLS1905 | MetaboLights
ProteomicsWhole cell iTRAQ proteome analysis of strain JA2
Here, we employed L-tryptophan metabolomics and iTRAQ based proteomic profiling of strain JA2 to decipher the molecular response. Wherein, L-tryptophan catabolism and molecular response of strain JA2 unexpected under chemotrophic conditions. Molecular response of L-tryptophan is essential to our u...
ORGANISM(S): Rubrivivax benzoatilyticus JA2 = ATCC BAA-35 
2024-11-27 | PXD055514 | Pride
Itraq Anoxygenic photosynthetic bacteria L-tryptophan metabolism 
ProteomicsOxidative Cyclization Reagents Reveal Tryptophan Cation-pi interactions
Raw data of the project "Oxidative Cyclization Reagents Reveal Tryptophan Cation-pi interactions"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-18 | MSV000093891 | MassIVE
ProteomicsProfiling Tryptophan Catabolites of Human Gut Microbiota and Acute-Phase Protein Levels in Neonatal Dried Blood Specimens
National screening programs use dried blood specimens to detect abnormal metabolism or aberrant protein function in infants shortly after birth, thus identifying disorders that are not clinically evident in the newborn period. Gut microbiota metabolites and immunological acute phase proteins are cap...
ORGANISM(S): Homo Sapiens 
2022-08-02 | PXD027606 | panorama
UnknownRegulation of blood pressure and glucose metabolism induced by L-tryptophan in stroke-prone spontaneously hypertensive rats.
Not available
S-EPMC3152873 | biostudies-literature
UnknownGenetic regulation of L-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis.
Not available
S-EPMC11046786 | biostudies-literature
MetabolomicsDivergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition
Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucity of knowledge regarding the biology of T. congole...
2021-07-20 | MTBLS2372 | MetaboLights
UnknownEngineering the L-tryptophan metabolism for efficient de novo biosynthesis of tryptophol in Saccharomyces cerevisiae.
Not available
S-EPMC11481463 | biostudies-literature
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
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