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GenomicsL1 retrotransposition in human iPSCs
Assessing L1 retrotransposition events in human iPSCs through deep sequencing.
PRJEB6145 | ENA
GenomicsTDP-43 safeguards the embryo genome from L1 retrotransposition
TDP-43 safeguards the embryo genome from L1 retrotransposition
PRJNA818863 | ENA
ProteomicsWidespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution
Somatic L1 retrotransposition events have been shown to occur in epithelial cancers1-8. Here, we attempted to determine how early somatic L1 insertions occurred during the development of gastrointestinal (GI) cancers. Using L1-targeted resequencing (L1-seq), we studied different stages of four color...
ORGANISM(S): Homo sapiens (Human) 
2015-08-11 | PXD001626 | Pride
Retrotransposon L1 Carcinoma Adenoma Colorectal cancer 
GenomicsDynamics of somatic L1 retrotransposition in the human brain
Profiling of L1 retrotransposition in human neurons across brain regions
PRJEB82316 | ENA
GenomicsSomatic L1 Retrotransposition of Colorectal Tumors
Somatic L1 Retrotransposition of Colorectal Tumors
PRJNA173389 | ENA
TranscriptomicsL1 retrotransposition in neurons is mediated by MeCP2
L1 retrotransposons are active elements in the genome, capable of mobilization in neuronal progenitor cells. Previously, we showed that chromatin remodeling during neuronal differentiation allows for a transient stimulation of L1 transcription. The activity of L1 retrotransposons during brain develo...
ORGANISM(S): Homo sapiens 
2010-11-11 | E-GEOD-21037 | biostudies-arrayexpress
TranscriptomicsL1 retrotransposition in neurons is mediated by MeCP2
L1 retrotransposons are active elements in the genome, capable of mobilization in neuronal progenitor cells. Previously, we showed that chromatin remodeling during neuronal differentiation allows for a transient stimulation of L1 transcription. The activity of L1 retrotransposons during brain develo...
ORGANISM(S): Homo sapiens 
2010-11-11 | GSE21037 | GEO
TranscriptomicsTDP-43 safeguards the embryo genome from L1 retrotransposition
We report that TAR DNA binding protein 43 (TDP-43), mutations in which constitute a major risk factor for amyotrophic lateral sclerosis (ALS), inhibits L1 retrotransposition in mouse embryonic stem cells (mESCs) and preimplantation embryos. Knockdown of TDP-43 resulted in massive genomic L1 expansio...
ORGANISM(S): Mus musculus 
2023-01-04 | GSE199197 | GEO
TranscriptomicsWidespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution
Somatic L1 retrotransposition events have been shown to occur in epithelial cancers1-8. Here, we attempted to determine how early somatic L1 insertions occurred during the development of gastrointestinal (GI) cancers. Using L1-targeted resequencing (L1-seq), we studied different stages of four color...
ORGANISM(S): Homo sapiens 
2015-08-10 | E-GEOD-63601 | biostudies-arrayexpress
TranscriptomicsIdentification of de novo LINE-1 (L1) retrotransposon integration sites in HeLa S3 cells by ATLAS-seq-neo (unselected insertions)
We used ATLAS-seq-neo to map the sites of integration of an engineered LINE-1 (L1) retrotransposon into the genome of HeLa S3 cells. In brief, we transfected cells with a plasmid-borne L1.3 element carrying a neomycin-resistance-based retrotransposition cassette, as well as a hygromycin-resistance c...
ORGANISM(S): Homo sapiens 
2019-04-03 | E-MTAB-7644 | biostudies-arrayexpress
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