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ProteomicsThe MAST kinase KIN-4 provides the Greatwall activity in C. elegans
Mitotic entry is triggered by the Cyclin B-Cdk1 kinase, which phosphorylates numer-ous substrates. The accumulation of these phosphorylated substrates relies on inhib-iting the opposing PP2A-B55 phosphatase. With its asynchronous cell divisions, the C. elegans embryo is an attractive model for disse...
ORGANISM(S): Caenorhabditis elegans 
2025-05-07 | PXD054396 | Pride
Cell cycle Phosphatase C. elegans Development Kinase 
TranscriptomicsA chromatin-modifying function of JNK during stem cell differentiation
Signaling mediates cellular responses to extracellular stimuli. The c-Jun NH2-terminal kinase (JNK) pathway exemplifies one sub-group of Mitogen-activated protein (MAP) kinases, which besides established functions in stress response, also contributes to developmental processes by an unknown mechanis...
ORGANISM(S): Mus musculus 
2011-12-18 | E-GEOD-25532 | biostudies-arrayexpress
UnknownQuantitative analysis of cytokinesis in situ during C. elegans postembryonic development.
Not available
S-EPMC4203819 | biostudies-literature
UnknownIrreversible glacier change and trough water for centuries after overshooting 1.5 °C.
Not available
S-EPMC12158768 | biostudies-literature
UnknownUV-C-Activated Riboflavin Crosslinked Gelatin Film with Bioactive Nanoemulsion for Enhanced Preservation of Fresh Beef in Modified Atmosphere Packaging.
Not available
S-EPMC11544885 | biostudies-literature
ProteomicsGreatwall depletion from Xenopus oocytes reveals a key role of the cyclin B/CDK1-PP2A-B55 balance in the coordination of meiotic events.
Meiotic progression relies on maintaining a precise balance between cyclin B/CDK1 activity and the phosphatase PP2A-B55. The latter is negatively regulated by the Greatwall kinase (Gwl). In maturing Xenopus oocytes, we show that the loss of Gwl and the subsequent hyperactivation of PP2A-B55 prevents...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2026-04-20 | PXD068132 | Pride
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions.
This SuperSeries is composed of the following subset Series: GSE30202: DNA binding factors shape the mouse methylome at distal regulatory regions [BIS_seq] GSE30203: DNA binding factors shape the mouse methylome at distal regulatory regions [ChIP-seq] GSE30204: DNA binding factors shape the mouse me...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30206 | biostudies-arrayexpress
UnknownThe MAST kinase KIN-4 carries out mitotic entry functions of Greatwall in C. elegans.
Not available
S-EPMC11961639 | biostudies-literature
UnknownEvolution of Escherichia coli to 42 °C and subsequent genetic engineering reveals adaptive mechanisms and novel mutations.
Not available
S-EPMC4166923 | biostudies-literature
UnknownProspective associations of C-reactive protein (CRP) levels and CRP genetic risk scores with risk of total knee and hip replacement for osteoarthritis in a diverse cohort.
Not available
S-EPMC6050083 | biostudies-literature
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