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Genomicsena-DATASET-MUG-26-02-2014-10:25:52:632-26 - samples
In this study we performed whole genome sequencing of plasma DNA (plasma-Seq) of 19 plasma-DNA samples from a total of 10 patients treated with anti-EGFR therapy. We demonstrated that development of resistance to anti-EGFR therapies is frequently associated with focal amplifications of KRAS, MET, an...
EGAD00001000748 | EGA
Genomicsena-DATASET-MUG-29-10-2013-10:52:10:827-14 - samples
In this study we performed ultra deep sequencing of genes associated with anti-EGFR resistance, such as KRAS, BRAF, PIK3CA, and EGFR in 17 plasma-DNA samples from a total of 10 patients treated with anti-EGFR therapy.
EGAD00001000688 | EGA
GenomicsResistance to anti-EGFR therapy in colorectal cancer
Monoclonal antibodies targeting the Epidermal Growth Factor Receptor (EGFR), such as cetuximab and panitumumab, have evolved to important therapeutic options in metastatic colorectal cancer (CRC). However, almost all patients with clinical response to anti-EGFR therapies show disease progression wit...
EGAS00001000582 | EGA
Genomicsena-DATASET-MUG-10-03-2014-08:56:10:089-189 - samples
In order to establish copy number profiles from the various samples we prepared libraries and subjected them to whole-genome sequencing at a shallow sequencing depth (0.1x)
EGAD00001000761 | EGA
Genomicsena-DATASET-MUG-10-03-2014-08:59:23:443-190 - samples
We utilized exome sequencing for DNA obtained from saliva (germline DNA) and the four spatially separated tumor foci and 3 corresponding lymph node metastases
EGAD00001000762 | EGA
Genomicsena-DATASET-MUG-10-03-2014-09:03:11:084-191 - samples
We used targeted deep sequencing to accurately establish the allele frequencies of the mutations identified by exome sequencing
EGAD00001000763 | EGA
GenomicsDivergence between high metastatic tumor burden and low circulating tumor DNA concentration in metastasized breast cancer
Circulating tumor DNA (ctDNA) was reported to represent a highly sensitive biomarker of metastatic cancer disease directly reflecting tumor burden and dynamics. Here we investigated the role of ctDNA in patients with metastatic breast cancer. In an index patient with more than 100,000 circulating tu...
EGAS00001000625 | EGA
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