Sort   by:  
 Page size 
TranscriptomicsLimited systemic sclerosis patients with PAH show biomarkers of inflammation and vascular injury
Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury Forty-nine PBMC samples were obtained from 21 lSSc subjects without PAH (lSSc-noPAH), 15 lSSc subjects with PAH (lSSc-PAH), and 10 healthy controls; three subjects provided P...
ORGANISM(S): Homo sapiens 
2010-10-27 | E-GEOD-19617 | biostudies-arrayexpress
TranscriptomicsExpression data from skin biopsies in pateints with systemic sclerosis treated with anti-TGF-beta, fresolimumab
Systemic sclerosis is associated with skin fibrosis thought mediated by TGFb. This open label clinical trial examines the effect of TGFb inhibition on skin gene expression. Patients 1-9 received two doses 1 mg/kg dose of fresolimumab at baseline and 3 weeks; patients 10-19 received a single 5 mg/kg ...
ORGANISM(S): Homo sapiens 
2015-06-05 | E-GEOD-55036 | biostudies-arrayexpress
TranscriptomicsExpression data from skin of mice treated subcutaneously with TGF-beta, IL-13 or TSLP for 7 days
Gene expression in mice skin stimulated with 3 different cytokines We used microarrays to detail the global programme of specific or common gene expression by 3 cytokines: TGF-beta, IL-13 and TSLP Mice skin were taken from the outlet of the 7-day pump (subcutaneous) and RNA was extracted.
ORGANISM(S): Mus musculus 
2013-10-31 | E-GEOD-34297 | biostudies-arrayexpress
UnknownSafety and efficacy of abatacept in early diffuse cutaneous systemic sclerosis (ASSET): open-label extension of a phase 2, double-blind randomised trial.
Not available
S-EPMC8713509 | biostudies-literature
UnknownSafety and Efficacy of Lenabasum in a Phase II, Randomized, Placebo-Controlled Trial in Adults With Systemic Sclerosis.
Not available
S-EPMC7497006 | biostudies-literature
UnknownSenescent Cells Accumulate in Systemic Sclerosis Skin.
Not available
S-EPMC10038878 | biostudies-literature
ProteomicsUbiquitin Proteomics Analysis of Systemic Sclerosis Lung Fibroblasts with or without KLHL42 knockdown
Systemic scleroderma (SSc) is an autoimmune disease which results in fibrotic production in the lung. Resultant SSC-pulmonary fibrosis is the main cause of mortality among SSc patients. From high throughput RNAi screening, we uncovered the ubiquitin E3 ligase KLHL42 as a potential pro-fibrotic media...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-14 | MSV000084800 | MassIVE
TranscriptomicsMolecular Signatures in Skin Associated with Clinical Improvement During Mycophenolate Treatment in Systemic Sclerosis
Skin gene expression signatures, including intrinsic subset, are associated with skin score/MRSS improvement during mycophenolate mofetil (MMF) treatment. Gene expression and intrinsic subset assignment were measured in SSc patients amd controls at baseline, and from biopsies of MMF-treated patien...
ORGANISM(S): Homo sapiens 
2013-04-09 | E-GEOD-45485 | biostudies-arrayexpress
Sort   by:  
 Page size