Sort   by:  
 Page size 
ProteomicsDbf4-Dependent Kinase Finetunes INO80 Function at Chromosome Replication Origins
The highly conserved Dbf4-Dependent Kinase (DDK) plays a pivotal role in the nucleus during S phase, where it directly phosphorylates the replicative helicase, the minichromosome maintenance (MCM) complex. This leads to the initiation of chromosome replication. However, aside from the MCM complex, f...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-04-06 | PXD053426 | Pride
Chromosome replication Phosphoproteomics Ino80 Cross-link ms Yeast ddk 
ProteomicsSpatially resolved mapping of histones reveal selective neuronal response in Rett syndrome
Rett Syndrome (RTT), a severe neurological disorder caused by loss-of-function mutations in the X-linked Mecp2 gene, results in profound life-long neurological dysfunction. RTT patients live a normal initial life until 12-18 months of age following which, a progressive accumulation of a wide range o...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-05 | PXD065165 | Pride
Spatial proteomics Mass spectrometry imaging Histone modifications Neuron Rett syndrome Laser capture micro-dissection 
ProteomicsMALDI imaging and LC-MS/MS-based fast, high-resolution spatial proteomics demonstrate cellular heterogeneity in situ
Highly specialized cells are fundamental for proper functioning of complex organs. Variations in cell-type specific gene expression and protein composition have been linked to a variety of diseases. Although single cell technologies have emerged as valuable tools to address this cellular heterogenei...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD044958 | Pride
Cellular heterogeneity Laser capture microdissection Imaging mass spectrometry Proteomics Data integration Dentate gyrus 
Sort   by:  
 Page size