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TranscriptomicsPolycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-76292 | biostudies-arrayexpress
GenomicsPolycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network [ChIP-Seq]
Malignant gliomas constitute one of the most significant areas of unmet medical need, due to the invariable failure of surgical eradication and their marked molecular heterogeneity. Accumulating evidence has revealed a critical contribution by the Polycomb axis of epigenetic repression. However, a c...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-76289 | biostudies-arrayexpress
TranscriptomicsPolycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network [RNA-Seq]
Malignant gliomas constitute one of the most significant areas of unmet medical need, due to the invariable failure of surgical eradication and their marked molecular heterogeneity. Accumulating evidence has revealed a critical contribution by the Polycomb axis of epigenetic repression. However, a c...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-76291 | biostudies-arrayexpress
TranscriptomicsCell reprogramming requires silencing of a core subset of Polycomb targets.
Transcription factor (TF)-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSC) is associated with genome-wide changes in chromatin modifications. Polycomb-mediated histone H3 lysine-27 trimethylation (H3K27me3) has been proposed as a defining mark that distinguishes the ...
ORGANISM(S): Mus musculus 
2013-03-09 | E-GEOD-44972 | biostudies-arrayexpress
GenomicSingle-Cell Analysis of Human Pancreatic Ductal Adenocarcinoma

Cancer-associated fibroblasts (CAFs) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell population consisting of several recently described subtypes, although the extent of CAF heterogeneity has remained undefined. H...

phs001840 | dbGaP
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