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ProteomicsEffects of FSCN1 inactivation on protein expression in human adrenocortical cancer cells
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 in e...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-18 | MSV000090738 | MassIVE
MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
TranscriptomicsNRSF/REST knockdown, and SF-1 overexpression and knockdown
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-43035 | biostudies-arrayexpress
GenomicsMechanisms of dosage-dependent regulation of gene expression by transcription factor SF-1
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-44224 | biostudies-arrayexpress
TranscriptomicsStudy of miRNA expression in childhood adrenocortical tumors
We studied the miRNA expression profile of a series of childhood adrenocortical tumors (ACT) and age-matched normal adrenal samples 25 ACT - 5 normal
ORGANISM(S): Homo sapiens 
2010-04-01 | E-GEOD-19856 | biostudies-arrayexpress
TranscriptomicsIdentification of genes regulated in adrenal glands of Ftz-F1 transgenic mice
SF-1, a transcription factor belonging to the nuclear receptor superfamily, has a pivotal role for adrenogonadal development in humans and mice. A constant feature of childhood adrenocortical tumors (ACT) is SF-1 amplification and overexpression. Using an inducible cellular system, here we show that...
ORGANISM(S): Mus musculus 
2010-06-12 | E-GEOD-5912 | biostudies-arrayexpress
TranscriptomicsIdentification of genes regulated by overexpressed SF-1 in human adrenocortical cells
SF-1, a transcription factor belonging to the nuclear receptor superfamily, has a pivotal role for adrenogonadal development in humans and mice. A constant feature of childhood adrenocortical tumors (ACT) is SF-1 amplification and overexpression. Using an inducible cellular system, here we show that...
ORGANISM(S): Homo sapiens 
2010-06-11 | E-GEOD-5911 | biostudies-arrayexpress
UnknownImpact of neonatal screening and surveillance for the TP53 R337H mutation on early detection of childhood adrenocortical tumors.
Not available
S-EPMC3808236 | biostudies-literature
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