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ProteomicsThe proteomic landscape of parkin-deficient and parkin-overexpressing rat nucleus accumbens: an insight into the role of parkin in methamphetamine use disorder
In recent years, methamphetamine (METH) misuse in the US has been rapidly increasing, and there is no FDA-approved pharmacotherapy for METH use disorder (MUD). We previously determined that ubiquitin-protein ligase parkin is involved in the regulation of METH addictive behaviors in rat models of MUD...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-04 | PXD065059 | Pride
Parkin  proteome  nucleus accumbens  mitochondria  methamphetamine 
TranscriptomicsA novel epidermal-specific role for arginase1 during cutaneous wound repair
Non-healing wounds are a major area of unmet clinical need that remain problematic to treat; therefore, improved understanding of pro-healing mechanisms is invaluable. The enzyme arginase1 is involved in pro-healing responses with its role in macrophages best-characterised. Arginase1 is also express...
ORGANISM(S): Mus musculus 
2021-07-07 | E-MTAB-10213 | biostudies-arrayexpress
TranscriptomicsRNAtag-Seq data generated from 22 host-relevant conditions in Campylobacter jejuni
RNAtag-Seq were used to investigate the transcriptomic landscape of C. jejuni under 22 growth and stress conditions, with 3 replicates from each condition. 5 extra repeats were created to replaces low-quality samples.
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2022-05-27 | E-MTAB-11309 | biostudies-arrayexpress
UnknownSubstantial decrease in CO2 emissions from Chinese inland waters due to global change.
Not available
S-EPMC7979821 | biostudies-literature
ProteomicsProfiling the surfaceome identifies therapeutic targets for cells with hyperactive mTORC1 signaling
Aberrantly high mTORC1 signaling is a known driver of many cancers and human disorders, yet pharmacological inhibition of mTORC1 rarely confers durable clinical responses. To explore alternative therapeutic strategies, herein we conducted a proteomics survey to identify cell surface proteins upregul...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-06-17 | MSV000083988 | MassIVE
Transcriptomicsp63 spatio-temporal control of cleft palate
Cleft palate is a common congenital anomaly with a live birth prevalence estimated to be 1:2500 live births, that results from failure of growth, elevation, adhesion and/or fusion of the palatal shelves during embryogenesis. Mutations in the gene encoding the transcription factor p63 result in cleft...
ORGANISM(S): Mus musculus 
2017-06-12 | E-MTAB-5289 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse sciatic nerve endoneurium and dorsal root ganglions isolated from pre-symptomatic and early symptomatic diabetes mellitus type 1 (DM1) model animals.
Even though the pathological changes, including decreased MNCV and progressive neuroanatomical alterations affecting neuronal structures are relatively well described, molecular mechanisms underlying DPN remain poorly understood. To analyze more extensively the molecular changes leading to the devel...
ORGANISM(S): Mus musculus 
2010-06-01 | E-TABM-987 | biostudies-arrayexpress
UnknownA triple-masked, randomized controlled trial comparing ultrasound-guided brachial plexus and distal peripheral nerve block anesthesia for outpatient hand surgery.
Not available
S-EPMC4009248 | biostudies-literature
TranscriptomicsmRNA expression of Qa2+ and Qa2- CD4+ thymocytes isolated from WT and miR-142-/- mice
Developing CD4+ T-cells in the thymus mature from CD69+Qa2- cells to CD69-Qa2+ T-cells. This maturation is accombanied by increased expression of CD62L and S1PR1 in Qa2+ cells, which allows mature T-cells to emigrate from the thymus to the periphery. However, miR-142-/- mice are characterized by an ...
ORGANISM(S): Mus musculus 
2013-06-14 | E-GEOD-47909 | biostudies-arrayexpress
UnknownA unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder.
Not available
S-EPMC6318768 | biostudies-literature
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