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TranscriptomicsLymphoid Priming in Human Bone Marrow Begins Prior to CD10 Expression with Up-Regulation of L-selectin
Studies of adult human hematopoiesis have until now relied on the expression of CD10 to define lymphoid commitment. We report a novel lymphoid-primed population in human bone marrow that is generated from hematopoietic stem cells (HSC) prior to the onset of CD10 expression and B cell commitment, and...
ORGANISM(S): Homo sapiens 
2012-08-14 | E-GEOD-35685 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of different types of cells in murine hair follicle to study cell type-specific gene expression.
Hair follicle matrix, outer root sheath, dermal papilla cells and melanocytes and a dermal fraction enriched in fibroblasts were FACS isolated from 4d backskins. Targets from two biological replicates of each were generated and the expression profiles were determined using Affymetrix Mouse Genechip...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3142 | biostudies-arrayexpress
TranscriptomicsSpo11-oligo mapping in S. cerevisiae Ctf19/CCAN kinetochore sub-complex mutant mcm21
During meiosis, crossover recombination is essential to link homologous chromosomes and drive faithful chromosome segregation. Crossover recombination is non-random across the genome, and centromere-proximal crossovers are associated with an increased risk of aneuploidy, including Trisomy 21 in huma...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-15 | E-GEOD-72683 | biostudies-arrayexpress
TranscriptomicsmiRNA Expression data of P4 stage hair follicle ORS cells from DTG (K14-rtTA,TRE-miR-125b) and control littermates
Increasing evidence suggests that microRNAs may play important roles in regulating self-renewal and differentiation in mammalian stem cells (SCs). Here, we explore this issue in skin. We first characterize microRNA expression profiles of skin SCs versus their committed proliferative progenies and id...
ORGANISM(S): Mus musculus 
2011-01-04 | E-GEOD-26395 | biostudies-arrayexpress
TranscriptomicsGene Expression data of P4 stage hair follicle ORS cells from DTG (K14-rtTA,TRE-miR-125b) and control littermates
Increasing evidence suggests that microRNAs may play important roles in regulating self-renewal and differentiation in mammalian stem cells (SCs). Here, we explore this issue in skin. We first characterize microRNA expression profiles of skin SCs versus their committed proliferative progenies and id...
ORGANISM(S): Mus musculus 
2011-01-04 | E-GEOD-26394 | biostudies-arrayexpress
TranscriptomicsDosage imbalance of NMD genes is associated with intellectual disability
Nonsense-mediated mRNA decay (NMD) functions to degrade transcripts bearing premature stop codon (PTC) and is a crucial regulator of gene expression. NMD and the UPF3B gene have been implicated as the cause of various forms of intellectual disability (ID) and other neurological symptoms. Here, we re...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-35420 | biostudies-arrayexpress
UnknownProteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling.
Not available
S-EPMC10959978 | biostudies-literature
TranscriptomicsFrequent occurrence of deletions in primary mediastinal B-cell lymphoma
Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of diffuse large B-cell lymphoma. PMBCL has been previously studied with a variety of genomic techniques resulting in frequent detection of chromosomal gains; however, chromosomal losses have been rarely reported. This finding contr...
ORGANISM(S): Homo sapiens 
2007-08-15 | E-GEOD-7383 | biostudies-arrayexpress
TranscriptomicsExpression data of P4 stage hair follicle early bulge and non-bulge ORS cells
Increasing evidence suggests that microRNAs may play important roles in regulating self-renewal and differentiation in mammalian stem cells (SCs). Here, we explore this issue in skin. We first characterize microRNA expression profiles of skin SCs versus their committed proliferative progenies and id...
ORGANISM(S): Mus musculus 
2011-01-04 | E-GEOD-26393 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine reveals fasting induces a biphasic adaptive metabolic response
Background; The gut is a major energy consumer, but a comprehensive overview of the adaptive response to fasting is lacking. Gene-expression profiling, pathway analysis, and immunohistochemistry were therefore carried out on mouse small intestine after 0, 12, 24, and 72 hours of fasting. Results; In...
ORGANISM(S): Mus musculus 
2009-05-13 | E-GEOD-8019 | biostudies-arrayexpress
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