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TranscriptomicsTranscript profiling of Lymphangioleiomyomatosis (LAM) nodules in Human Patients
Lymphangioleiomyomatosis (LAM) is characterized by cystic lung destruction caused by smooth, muscle-like LAM cells which have mutations in the tumor suppressor genes Tuberous Sclerosis Complex (TSC) 1 or 2, and the capacity to metastasize. Since chemokines and their receptors function in chemotaxis ...
ORGANISM(S): Homo sapiens 
2008-12-30 | E-GEOD-12027 | biostudies-arrayexpress
ProteomicsProteomic study of evolved P. aeruginosa strains grown in S. aureus- and K. pneumoniae-conditioned media
In this research, Pseudomonas aeruginosa underwent evolution in the supernatant of either S. aureus (SA) or K. pneumoniae (KP). Through this evolution process, we enriched a sufficient number of bacterial cells along with their corresponding proteins. Following 15 cultivation cycles, notable changes...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2025-05-21 | PXD059669 | Pride
Supernatant Laboratory evolution Proteomics K. pneumoniae S. aureus P. aeruginosa 
TranscriptomicsEstrogen and mTORC1 dependent genes in the uterus of uterine-specific Tsc2-null mice
To uncover genes regulated by mTORC1 and estradiol in uterine Tsc2-null LAM like cells, we performed RNAseq on uteri from 12-week old wild-type (WT) and uterine-specific Tsc2-null (KO) mice that were either untreated (intact), oopherectomized (ovx) or oopherectomized + treated with 17β-estradiol pe...
ORGANISM(S): Mus musculus 
2016-02-26 | E-GEOD-78701 | biostudies-arrayexpress
TranscriptomicsHuman Trophoblast Responses to P. gingivalis Infection
Porphyromonas gingivalis is a periodontal pathogen that is also associated with preterm low birth weight delivery. We investigated the transcriptional responses of human extravillous trophoblasts (HTR-8) to infection with P. gingivalis. Over 2000 genes were differentially regulated in HTR-8 cells ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-19810 | biostudies-arrayexpress
GenomicsIdentification of Host-Chromosome Binding Sites and Candidate Gene Targets for KSHV LANA
LANA is essential for tethering the KSHV genome to metaphase chromosomes and for modulating host-cell gene expression, but the binding sites in the host-chromosome remain unknown. Here, we use LANA-specific chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq) to identify ...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-34890 | biostudies-arrayexpress
TranscriptomicsTranscript profiling of Lymphangioleiomyomatosis (LAM) nodules in Human Patients
Lymphangioleiomyomatosis (LAM) is characterized by cystic lung destruction caused by smooth, muscle-like LAM cells which have mutations in the tumor suppressor genes Tuberous Sclerosis Complex (TSC) 1 or 2, and the capacity to metastasize. Since chemokines and their receptors function in chemotaxis ...
ORGANISM(S): Homo sapiens 
2008-12-31 | GSE12027 | GEO
ProteomicsProfiling the LAM family of contact-site tethers provides mechanistic insights into their regulation and function
Membrane contact sites are molecular bridges between organelles that are sustained by tethering proteins and enable organelle communication. The endoplasmic reticulum (ER) membrane harbors many distinct families of tether proteins that enable the formation of contacts with all other organelles. One ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051014 | Pride
Membrane contact sites  endoplasmic reticulum  lam protein family  proximity labelling  abolish 
ProteomicsProfiling the LAM family of contact-site tethers provides mechanistic insights into their regulation and function
Membrane contact sites are molecular bridges between organelles that are sustained by tethering proteins and enable organelle communication. The endoplasmic reticulum (ER) membrane harbors many distinct families of tether proteins that enable the formation of contacts with all other organelles. One ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-03-10 | PXD051047 | Pride
Membrane contact sites  endoplasmic reticulum  lam protein family  proximity labelling  abolish 
UnknownTargeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM).
Not available
S-EPMC9772321 | biostudies-literature
UnknownCopper(ii)-catalyzed synthesis of multisubstituted indoles through sequential Chan-Lam and cross-dehydrogenative coupling reactions.
Not available
S-EPMC9055228 | biostudies-literature
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