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Dysferlin is expressed in skeletal and cardiac muscle. However, dysferlin deficiency, namely limb girdle muscular dystrophy 2B (LGMD2B) and Myoshi myopathy, results in skeletal muscle weakness and spares the heart. This dichotomy could be caused by differential regulation of protective mechanisms. T...
ORGANISM(S): Mus musculus 
Comparitive gene expression in skin between mice maintained in microgravity (0g) and normogravity (1g) environment. Six male C57Bl/J10 mice were housed for 91 days in the specially designed \Mouse Drawer System\ in weightlessness aboard the International Space Station. Three wild-type mice (WT) and ...
ORGANISM(S): Mus musculus 
HeLa cells were un-transfected or transfected with specific siRNAs (20µM) targeting IKAP/hELP1 or non-specific siRNAs against GFP. Same experiment was done by stimulating the cells for 1 hour with TNF-a (200U/ml). conditions: 1/untransfected 2/siRNAs IKAP 3/untransfected + TNF-a 200U/ml 1h 4/siRNAs ...
ORGANISM(S): Homo sapiens 
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