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TranscriptomicsMolecular and transcriptional characterization of chromosome 17p loss in chronic lymphocytic leukemia, experiment A
Distinct genetic abnormalities such as TP53 deletion at 17p13.1, have been identified as having an adverse prognostic relevance in B-cell chronic lymphocytic leukemia (B-CLL). Conventional cytogenetic studies have shown that TP53 deletion in B-CLL is associated predominantly with 17p loss resulting ...
ORGANISM(S): Homo sapiens 
2008-11-11 | E-GEOD-9992 | biostudies-arrayexpress
TranscriptomicsMolecular and transcriptional characterization of chromosome 17p loss in chronic lymphocytic leukemia, experiment B
Distinct genetic abnormalities such as TP53 deletion at 17p13.1, have been identified as having an adverse prognostic relevance in B-cell chronic lymphocytic leukemia (B-CLL). Conventional cytogenetic studies have shown that TP53 deletion in B-CLL is associated predominantly with 17p loss resulting ...
ORGANISM(S): Homo sapiens 
2008-11-11 | E-GEOD-11036 | biostudies-arrayexpress
TranscriptomicsDioxin exposure of human CD34+ hemopoietic cells induces gene expression modulation that recapitulates its in vivo clinical and biological effects
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has a large number of biological effects, including skin, cardiovascular, neurologic disease, diabetes, infertility and cancer. We analysed the in vitro TCDD effects on human CD34+ cells and tested the gene expression modulation by means of microarray analy...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-24193 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human purified plasma cells (PCs) obtained from 90 newly diagnosed multiple myeloma (MM) reveals a distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma
Background and objective: The chromosome 13 deletion (del(13)) represents one of the most frequent chromosomal alterations in multiple myeloma (MM). del(13) is associated with an unfavorable prognosis, although there is an increasing agreement that its prognostic relevance has to be related to the p...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6365 | biostudies-arrayexpress
TranscriptomicsIdentification of MicroRNA Expression Patterns and a MicroRNAs/mRNA Regulatory Network in Multiple Myeloma
To date, little evidence of miRNA expression/deregulation in multiple myeloma (MM) has been reported. To characterize miRNA expression profiling of MM plasma cells (PCs) and integrate miRNA expression data with other molecular features of MM patients, global miRNA expression profiles were generated ...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-17498 | biostudies-arrayexpress
TranscriptomicsGenomic approach in B-cell Chronic Lymphocytic Leukemia: molecularly distinct subgroups of patients with 13q14 deletion
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by a highly variable clinical course that reflects its heterogeneous genomic pattern. To better define molecular subtypes of the disease, we performed SNP and gene expression profiling microarray analyses in a panel of early stage (Binet A...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-16746 | biostudies-arrayexpress
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